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Show Using Chick as a Model Organism in Understanding Neural Tube Closure William M cKuLin and A nthea Letsau Departmont of Human Genetics Em hi j^ Formation nnd development is? process oF rrn ^-|| i -F. In r^ ?Ferializ?1 "ion of cell cellular ¦n \ niknnnihnji Vurpl lut. C'lmun Vi .1 ..Ti. M. k,. ,d JMr .xiflirH L^IHU lk[Linnrni nf Ihiun I i u Such sfMtlallHtlon la eAfcnt 1n s««al niMfcl organisms In I)k ^ _>|-lii. n in j^.i^l^f l|rUir M/j..dntf-nbr^j I -1 ¦ I doiue Irmalwadie larerdl e-bn^dilonand ruwun of epidermal cdli along die dorsoventral ceaa Ii t haranerlztd by well known ernbr>"O5 aho display pnb*yon ^ cellular 5p**ri3l"i?1 H?n. For ex hiickneuraltubt closure. epVtefrnal cells- of tht neural Fold elevate 1 h rough change In ?h?pt to Form the neu ral gro^?vt. edfje^fllhe^ntunlly Fuw^^ng ih? dorwl nidhneof 1h* q roo1^ to form 1 he neural 1 u t^. Ii lichuieAlefn clue Lon^fvadon exl^^ baweentfwfunalonal pio- rJriiSei ur Dirjiuprill j r>iiSdl i^iiUre JFid rj h Klk r^JrUl JTKJn AiarfrH* f-ji ¦ >.j ji" i'ma1 cli jr che fe I Thar, art i- |lm»i: for dsi« k biure i n • | >l ill Fill ......U MjUi lLH-1 IN i_riM>T YHNkri Will be ¦||lll for rwurih u te ri in jj1 u h>t?ifcJi&itionto?how 1 hi^retitionship ChVkhfornologue? l+irit Hire kr>?wn to be require ror doiwk toure h?ve oeen aen^?1ed. m?"k^. nnd oound to whsr? rnounu hV k embryos The?p em hryo* have th^P be^P visually screened for the pre5er>re oF labeled aenet"^ tr?ni;cript?. Using \h~t$ method, v^e have shown 1 hat jjx hornologues to Drowphil? dsrsa I or^n group genes ?re. «f pressed at the right llrne sr>d pla^e. to function m n^uml tube formritrop Fu nhermorejo refine our u no^rsirindinp of c hV k neurul?1 "non, e.m oryos ?re. cross sectioned 1o aener?1e a l?1e.ral vfcgw of genetic F^11e.rns In 1 he. developmci neural tube |