OCR Text |
Show ; Coronary Arteries from Mice with Cardiac-Selective Deletion of the Insulin Receptor are Resistant to Dysfunction Evoked by Pressure-Overload Earl Healy [J David Symons) College of Health, Department of Exercise and Sport University of Utah Diabetic parents with cardio^K u hr disease OC^ have a Y^rw pronnos"*? than non indi*duals who develop Cv"D AHh?"^h1h?m«hannm^lre5pcin5ible for thin? l^ra twolfladinfl^rindidntPMnrlucthvp^rfll^r^fTiin^ndin^ulinrHi^ince To completely separate Hie effects of hyp^rglYcernia from insulin rwTrtance, cardie selective insulin receptor knockout nn« H p* CIRKC were devetoped. These rnice have normal glucose conceM ratrans but iKkinmlin^icjn^lin^inth^cnidirTT rl\ 1 he contribution Frorn inpriir^H m?ulin 5H3rmlmcjppr5P^r"in be p^lurit^H In a previous ?tudy 1 li- - v......m ii hyi >in- '\ '¦" vll: i PW i K1- ¦ ivpe(^ ......by pi* n ^trlctton.....¦> I l+ifl transve^eKirta. Thurestriricnpindurp^^^on^t^nt pe^sura overload on the heari. Heartifron CIRKO rnicefl^hioHed^r€?1?r left venii^u^rdy&runct"on3rd5uberxfc>rardi?lfibro5iicorripared1oWT heart? In^reawd jubpixtorardialfibrosii could result Frorn mi paired coronary blowJ flow in ClflKO vs. WTrnice. As sue h, wt tested Ififl hypothe5i5 that roronary vascular Function ninipair€d m CIRKG vs, ^VT ni« m responw toLVH. Fourtwr cLny* aher r^trrtinn the *srta to *:auw LVH we as*e?wd oororury vaK ular Fu n^tVm using wire rny^raphy. Ou" ^int of ^is^ular function i? the ability of the vessel lovasorelax or increase rt^ dianewr. Coni r^ry to our we obwrved that pixfctheiium dep^ndeni vHi»ielaKatr5n v^5 a bofished in W Hinrnial*. ou1 in ClflKO mVe. Furtherrnora. the extent oF juberxfc*:ardia I fibrous was similar betv^een groups naryi"ur>rtionv^sintKtlnCIRKO rnice, bu1 subenctxardial nbros^ persisted. dvsFundcn of the relatively l?"C|p epic?rcT«l coronary vessels pva luated m thp present s1 uc*v Is not responsible. lnsw?c^ subenctxardial nbrosj? ir CIRKO rnice hkehy results frorn mV rovaK u lar dysfunct™. |