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Show Mfctartttort Selective Insulin Resistance in the Vasculature Leads to Hypertension Michaal Clark, Shawna McMillin [J, David Symons) D apart m«nl of Exarcisa & Sports Science, Col lag a of Health, University of Utah Tl ' i . .1'.'. I I'.' ll .'I I." "pin......."¦ .....-I'"......11- -. I- ¦ I H ¦. II - I I'...... Il7|.......-I HI teltation of phmphalfclyllnoiiiGl 3-kj nase IMI^k: -.¦¦ I ftocem klmse B(Ak" bylruulln Increases, trtdochellal merit auds iyntfuie fe#JD5> actirtlfl leading to gasodllaiarlon Inconiidii.aaigacintf elnkiri«e^tkRlandlbMKl/2|bylnidliniilrTiu^ititfidcrfhelln-l and promotes n- loial Iniu fin itcepinM krwcbaift mkfi fTTfl-Ifi 7-) are nul fcr tfie Irajfln receptor (TfiL re-aip*eialonof fc mine brain, livtr and teca-Lell*. These mite do nor possess manycirihfrnwtibslk: wlih dto-lnducedinidhn re^icariLe In bk>rfvtiiekfrorn I Ir-IK-V- vs ^iHiypefiVF. mice, i niulln rnediiied downicream ilgnah n^ r/Ati and Effl Ifl fc ibitnc a nd eN05 sfpceuion arnd bbauffahil- I urchermcire. ik days aftei impla m m^ lelernei i y unit a, 4S-li our averages of mean ucetlalpfet-l-^l were similar between 11R-IM-V- (1Q-1 ± 11 and WI mke4ioe±l fc r=a-10 per q ioupj Became a bwnte orkiujlbi dgnabig b rwt ohawwd cllnkall^ we cornpa ied ihtianie.rarlBbfcsbe[wwn mice lhaiconsumed a h^h-fac diei 1^5%fai. HI) coirwielhacconsunwd iiandaid icidenttnow [\0 _ fatCOri n=10 pec 5?o jpl fci ID week? dixose mioferarKe, hyper gl>^ern ^ h^pei insuhnemia, ar>d obeslcy iill f>rf?_05] were pie^ntlnHF V3 COHmfce Fu ri hermoren msull n-5tlmulat«J ptioapho IpJ-ftkl was reduced and p-EF^cotal-ERK was Increase^ in 1 he rasculatu re gF HF vs. Con m ce. eMOS bloavallabilrty also was reduced In HchhJ vessels from Hf vt LOHmke 4a-hour telemetry resukt indicated that hypertenakin «dsted ^p<0 Dbj In hFU23±l?ut_Ccn ^lWil^mlce Thu^hypercenEJondoetnocdevelc-pm rnlcewrchnon-selectlueirnpanrmenioflntulln-rnedbceG slcjnail1ransduc1cn^l.e,TTr-lR7-mlcel. However, selective resrsta nee to insulh 'ii\<iu:"H\ .i.......i. rase jlatu re of mfce-wBi Jet Induced obetrty Uev HF mlcel leads to |