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Show CHAPTER 3 METHAMPHETAMINE-INDUCED DOPAMINE TRANSPORTER COMPLEX FORMATION AND DOPAMINERGIC DEFICITS: THE ROLE OF 02 RECEPTOR ACTIVATION Introduction Methamphetamine (METH) is a highly addictive psychostimulant whose abuse has significant individual and societal costs. One concern associated with METH abuse is the potential for long-term dopaminergic deficits. For example, METH abusers have reduced striatal dopamine (OA) transporter (OAT) densities (McCann et aI., 1998; Wilson et aI., 1996); an effect that has been associated with motor slowing and memory impairment (Volkow et aI., 2001) and may be related to psychiatric symptoms (Sekine et aI., 2001). Studies involving repeated, high-dose oxidative stress rodents indicate there administrations of METH are many effects caused including, but not by limited to, (for review, see Brown and Yamamoto, 2003 ; Krasnova and Reprinted with permission of the American Society for Pharmacology and Experimental Therapeutics. All rights reserved. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 335, No.1 Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics 166660/3624361 JPET 335:207-212,2010 Printed in U.S.A. |
