| OCR Text |
Show 2 associated with approximately 107,000 emergency room United States in 2006 (Office of Applied Studies, 2007). a admissions in the Individuals experiencing commonly present with agitation, acute psychosis, suicidal METH overdose ideation, tachycardia, hypertension, and dilated pupils. Fatalities associated with METH use occur cerebrovascular often from pulmonary edema, hemorrhage, ventricular fibrillation, hyperpyrexia (Cruickshank and pulmonary cardiac failure, acute METH Furthermore, Dyer, 2009). conqestion, commonly experience psychiatric symptoms including anxiety, or users depression, insomnia, and psychosis (Gonzales et aI., 2009). Prolonged use of METH is also associated with neurooognitive impairments (Barr et aI., 2006). METH is widely abused because of its positive effects including arousal, reduced fatigue, reduced appetite, behavioral and disinhibition, euphoria. Negative effects of METH include rapid speech, agitation, elevated pulse, aggression, nervousness, and agitated, paranoid state with paranoia. At high doses, hallucinations that Although METH, schizophrenia (8ell, 1973). closely METH produces an resembles and the related paranoid amphetamine (AMPH), have high abuse potentials and are available illicitly, they are clinically used for the treatment of attention deficit disorder, obesity, and narcolepsy (Miller et al., 1993). METH is bioavailable through multiple routes of administration and can be snorted, smoked, injected, agonist at or orally administered. monoaminergic receptors, including METH acts those for as an indirect dopamine (DA), serotonin (5-HT), and norepinephrine (NE). As the focus of this dissertation and |
