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Show CHAPTER 2 MECHANISMS UNDERLYING METHAMPfiETAMINE-INDUCED DOPAMINE TRANSPORTER COMPlEX FORMATION Introduction Repeated, hiqh-dose methamphetamine (METH) administrations cause persistent striatal dopaminergic deficits (for review, see Gibb et aI., 1994, Brown and Yamamoto, 2003). While mechanisms contributing to this phenomenon remain to be elucidated fully, dopamine (DA; Wagner et aI., 1983; Schmidt et aI., 1985), the DA transporter (OAT; Schmidt and Gibb, 1985; Fumagalli et aI., 1998), hyperthermia (Bowyer et aI., 1992), glutamate (Sonsalla et aI., 1989, Mark et aI., 2004), microglial activation (LaVoie et aI., 2004; Thomas et aI., 2004), and reactive species (Giovanni et aI., 1995; Yamamoto and Zhu, 1998; Gluck et aI., 2001, Imam et aI., 2001) are among the contributing factors. Repeated, high- dose METH injections also rapidly (within 1 h after the final METH administration) decrease plasmalemmal DA uptake, as assessed in striatal synaptosomes Reprinted with permission of the American Society for Pharmacology and Experimental Therapeutics. All rights reserved. TI'1E JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 329, No.1 Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics 145631/3450355 JPET 329:169-174,2009 |
