| OCR Text |
Show 30 Figure 2.4. SCH3390 pretreatment does not attenuate OAT complex formation (panel B), the decreases in [3H]OA uptake (panel C), nor the OAT monomer loss following METH-treatment (panel 0). Rats received four injections of METH (7.5 mg/kg/injection; s.c.; 2-h intervals) or saline vehicle (1 ml/kg/injection; s.c.; 2-h intervals) and were sacrificed 24 h later. Thirty min prior to each injection, rats were pretreated with SCH23390 (SCH; 0.5 mg/kg/injection; i.p.) or saline vehicle (1 ml/kg/injection; i.p.). Panel A presents a representative blot of saline/saline (lane 1), saline/METH- (lane 2), SCH/saline- (lane 3), and SCH/METH- (lane 4) Molecular weight (kO) is shown adjacent to a representative treated samples. blot. Columns represent the means and vertical lines 1 SEM determinations in 12-14 rats. *Values different from saline-treated controls (p :5 0.05). |
