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Title Mystery of DNA replication, The
Subject DNA--Synthesis
Description The 43rd Annual Frederick William Reynolds Lecture.
Creator Lark, Karl G.
Publisher University of Utah Press
Date 1980-03-05
Date Digital 2008-05-29
Type Text
Format application/pdf
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,83
Source QP624 .L37
Language eng
Relation Digital reproduction of "The Mystery of DNA replication," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s65q4t2n
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-08-04
ID 319398
Reference URL

Page Metadata

Title Page5
Description THE MYSTERY OF DNA REPLICATION 5 was possible easily to rebuild a complete new molecule. Although a great deal of physical and structural research had preceded the model, producing crucial data important to the structure, the excitement that was caused by the model was not due to these data, but rather in the consequences the model had for genetics itself, since it provided an explanation of how the genetic material could copy itself. This was one consideration used by Watson and Crick to decide upon a likely structure for DNA. It was well established that genes were arranged as beads on a string and that the linear arrangement of these genes was maintained with very great integrity. It thus was clear that the Watson-Crick helix could easily explain the properties of genetic inheritance. The double helix was a long double-stranded string or rope. By simply unwinding the two strands, the context of the genes in their relation one to the other was maintained, and by copying each strand again, another double-stranded duplicate of the original parent could easily be synthesized. Since there were two original templates two copies would be produced. On paper the faithful copying of DNA was exquisitely simple and one of the major attractions of the model of Watson and Crick. A second area in which the double helix focused scientific thought was how the phenotype or physical and chemical characteristics of the organism were expressed. How was the information contained in these genes translated to produce the inherited characteristics which made the descendants of an organism resemble the parents? Because attention had been focused on the chemical characteristics of proteins (as enzymes and at one time as possible sources of genetic material), a great deal was known about the chemical characteristics of these large molecules of which the cell is composed. Thus, the question was reworded and changed from "How does the descendant resemble the parents?" to "How are the chemical molecules (in particular proteins) found in the descendant reproduced from the genes received from the parent?" In summary, after the discovery of the Watson-Crick helix two questions became paramount in the minds of many geneticists and
Format application/pdf
Identifier 011-RNLT-LarKK_Page5.jpg
Source Original Manuscript: The mystery of DNA replication by Karl G. Lark.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319366
Reference URL