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Title Mystery of DNA replication, The
Subject DNA--Synthesis
Description The 43rd Annual Frederick William Reynolds Lecture.
Creator Lark, Karl G.
Publisher University of Utah Press
Date 1980-03-05
Date Digital 2008-05-29
Type Text
Format application/pdf
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier http://content.lib.utah.edu/u?/reynolds,83
Source QP624 .L37
Language eng
Relation Digital reproduction of "The Mystery of DNA replication," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s65q4t2n
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-08-04
ID 319398
Reference URL https://collections.lib.utah.edu/ark:/87278/s65q4t2n

Page Metadata

Title Page25
Description THE MYSTERY OF DNA REPLICATION 25 which can produce extra copies of mutated DNA even when the cells are growing in a very poor environment. Thus, they go on making many, many copies of DNA with a ten to a hundred times higher frequency of mutations. Occasionally, one of these mutants may have the capability to grow in the new environment. Thus, bacteria have evolved a way with which to deal with varying environments. When they move to a good environment, they automatically prepare a system to produce mutants that will be capable of dealing with a bad environment. Moreover, they can increase the probability of these mutations by replicating their DNA endlessly. Thus, bacteria living in a constant environment use a replication system which avoids mistakes and faithfully copies their genes, but when the environment is highly variable, they can construct a second system which can make mistakes and thus increase genetic variation and the probability of adapting to the environment. Complexity can often increase flexibility. Perhaps, like repair, this is another "miracle" of nature. What Next? Scientists have never lost the insatiable curiosity of small children. This curiosity combined with an ability to recognize simple truths in a mass of information can result in the statement of a "law" of nature. Perhaps the greatest simplification in biology is the assumption underlying the theory of evolution, that the inheritance of an organism is variable and that heritable changes which improve the chances of survival will survive with the organism and therefore accumulate. Destructive changes will die with the organism. A corollary of this is that most of the genetic information of an organism is optimally suited to insure its survival in its present environment. Belief in this corollary is a prejudice shared by most biologists, particularly molecular biologists who have had the opportunity to observe populations of microorganisms adjust in this way to artificial environments created in the laboratory. When the same procedure or mechanism is found in many different organisms, it is usually safe to conclude that there is a
Format application/pdf
Identifier 031-RNLT-LarKK_Page25.jpg
Source Original Manuscript: The mystery of DNA replication by Karl G. Lark.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319386
Reference URL https://collections.lib.utah.edu/ark:/87278/s65q4t2n/319386