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Title Mystery of DNA replication, The
Subject DNA--Synthesis
Description The 43rd Annual Frederick William Reynolds Lecture.
Creator Lark, Karl G.
Publisher University of Utah Press
Date 1980-03-05
Date Digital 2008-05-29
Type Text
Format application/pdf
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,83
Source QP624 .L37
Language eng
Relation Digital reproduction of "The Mystery of DNA replication," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s65q4t2n
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-08-04
ID 319398
Reference URL

Page Metadata

Title Page18
Description 18 KARL G. LARK 4. Discontinuous replication. DNA polymerases, the enzymes which add successive subunits to the growing DNA chain, can work only in one direction. (A) Because of the opposite polarity of the two strands of the double helix this posed a problem in DNA replication, since only one template could be copied continuously. Okazaki proposed that synthesis was continuous on one strand, but discontinuous on the other. (B) Subsequent experiments proved that the discontinuous synthesis did, indeed, occur. However, discontinuities were eventually observed on both sides of the double helix, often persisting even when they were located some distance behind the replication fork. (C) This has suggested that discontinuity itself serves some function which increases the probability of a cell's survival.
Format application/pdf
Identifier 024-RNLT-LarKK_Page18.jpg
Source Original Manuscript: The mystery of DNA replication by Karl G. Lark.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319379
Reference URL