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Title Mystery of DNA replication, The
Subject DNA--Synthesis
Description The 43rd Annual Frederick William Reynolds Lecture.
Creator Lark, Karl G.
Publisher University of Utah Press
Date 1980-03-05
Date Digital 2008-05-29
Type Text
Format application/pdf
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,83
Source QP624 .L37
Language eng
Relation Digital reproduction of "The Mystery of DNA replication," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s65q4t2n
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-08-04
ID 319398
Reference URL

Page Metadata

Title Page8
Description 8 KARL G. LARK the rise and success of molecular biology as his central paradigm. Since the main thread of my story concerns another scientific problem, I will simply summarize the results of these productive years. From the Watson-Crick model there arose what is known as the central dogma of molecular biology. It states that DNA is the repository of all the information needed to construct and guide the activities of a cell. The DNA is faithfully duplicated by unwinding and copying the two strands to give daughter helices each of which is distributed into a new daughter cell accounting for the genetic inheritance of the cell. The cell's phenotype or character was to be expressed by the following mechanism: it had been known that cells were composed of proteins and that the proteins represented both the structural building blocks of cells, as well as the functional machines which allowed the chemical reactions within cells to proceed. All cells require energy and replacement of material within them to function and stay alive. The chemical reactions, often extremely complex, which go into maintaining the cell's survival are all catalyzed by proteins. Proteins are really strings of smaller molecules or subunits connected together and wound into a shape capable of performing some function, similar to bending and coiling a piece of wire until it assumes a shape. If the instructions for the coiling are extremely precise and if one measures very carefully the lengths which are bent and twisted, the shape constructed can be faithfully reproduced. With the discovery of the structure of DNA and the previous knowledge that proteins were really coiled strings of amino acid subunits it was believed that the DNA was copied and the transcripts were sent out of the nucleus into the rest of the cell where they were translated into strings of peptides which then coiled up to form proteins. The simplicity of the dogma is evident: DNA is a string; it is copied onto another molecule which is also a string; the other molecule is somehow translated into yet a different molecule composed of many different kinds of subunits also strung together. Information is transmitted by reading in one dimension along a line; one does not have to encompass a surface or three dimensions. Each protein (or chain of amino acids) represented a piece or segment of DNA and the
Format application/pdf
Identifier 014-RNLT-LarKK_Page8.jpg
Source Original Manuscript: The mystery of DNA replication by Karl G. Lark.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319369
Reference URL