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Title Mystery of DNA replication, The
Subject DNA--Synthesis
Description The 43rd Annual Frederick William Reynolds Lecture.
Creator Lark, Karl G.
Publisher University of Utah Press
Date 1980-03-05
Date Digital 2008-05-29
Type Text
Format application/pdf
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,83
Source QP624 .L37
Language eng
Relation Digital reproduction of "The Mystery of DNA replication," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s65q4t2n
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-08-04
ID 319398
Reference URL

Page Metadata

Title Page4
Description 4 KARL G. LARK growth were complex and that bacteria that had adjusted to grow in different environments produced different enzymes. At the time of my prelims, one of the former graduate students from our department (Mel Cohn) was in Paris studying this problem with Jacques Monod. We received all of the latest reports on these studies from him. I had expected Delbriick's lecture that afternoon to be on phage, but it was not. He discussed fruit flies and corn and used these to present two unsolved genetic enigmas: how large are genes and how close together on the chromosome are they? Why did the expression of genes (that is, the cell properties that were inherited) change depending upon where the gene was located? (If you changed a gene's position in the string of genes that comprised the chromosome, or moved the gene to a different chromosome, the property was altered, or sometimes not expressed.) I was both surprised and puzzled that Delbriick felt that these problems were more important than the phage and bacterial problems that we usually discussed in the summer. At that time good genetic data had not yet been obtained with either phage or bacteria, and Delbriick was not one to let the forest obscure the trees. A year and a half later I graduated and my thesis was presented at the 1953 virus and phage symposium at Cold Spring Harbor. I had shown that ions could alter bacteriophage protein (I believed that their shape was altered), making them resist the tendency to unfold when heated. I had no idea of the general importance of this concept, but it along with many other interesting new findings was overshadowed by the double helical structure for DNA proposed by Watson and Crick. Their model marked a transition, indeed a turning point, in the study of biology. Studies focused on the nature of genetic material and how this material functioned were brought into sharp relief. The proposed structure provided an explanation of how the inheritance of organisms could be carried by a single molecule. The molecule was composed of two halves, mirror images, which when separated could be copied and two new double-stranded molecules synthesized. Because each half-structure contained all of the information needed to build the other half, it
Format application/pdf
Identifier 010-RNLT-LarKK_Page4.jpg
Source Original Manuscript: The mystery of DNA replication by Karl G. Lark.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319365
Reference URL