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Title Mystery of DNA replication, The
Subject DNA--Synthesis
Description The 43rd Annual Frederick William Reynolds Lecture.
Creator Lark, Karl G.
Publisher University of Utah Press
Date 1980-03-05
Date Digital 2008-05-29
Type Text
Format application/pdf
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,83
Source QP624 .L37
Language eng
Relation Digital reproduction of "The Mystery of DNA replication," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s65q4t2n
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-08-04
ID 319398
Reference URL

Page Metadata

Title Page7
Description THE MYSTERY OF DNA REPLICATION 7 microscope was becoming a more widely used tool, since only this instrument was useful for determining the structures of bacteria and their viruses. All of this information was rapidly transmitted within the phage group and it was in a letter from a student friend in Cold Spring Harbor, George Streisinger, that I learned in the early summer of 1956 that a new enzyme had been discovered by Arthur Kornberg, which copied and synthesized DNA. Kornberg was not associated with the phage group but was developing a new school of biochemistry which had its original inspiration in the work of Herman Kalckar, a Danish biochemist from the phage group. Kalckar believed that nucleoside triphosphates might be the precursors of DNA (nucleotides were known to be the subunits which comprise DNA). Kornberg pursued this possibility using radioisotopic assays and biological criteria in a way never before employed by biochemists. This work was to be developed extensively, as Kornberg surrounded himself with biologists, immunologists, and geneticists in the prototype of a modern department of molecular biochemistry. I was associated with a new school of research which also grew out of the microbiology of Stephenson and Gale. Gale had criticized the practice of biochemistry as being similar to destroying a house with a bomb and then attempting to reconstruct the arrangement of rooms and furniture from the debris. Studying with Ole Maaloe in Denmark, I came to appreciate an experimental style which reconstructed a cell, not by destroying it, but by studying its reaction to changes in the environment. This in vivo approach was to become increasingly valuable as the techniques for using radioisotopes and genetics became more generally available. The Fruits of the Double Helix When I returned in 1956 to my first job, the stage had been set for one of the most dramatic sequences of discovery and clarification in the history of any science. The progress in this area was so fast and extensive that only ten years later Gunther Stent wrote a book concluding that scientific progress was coming to an end, using
Format application/pdf
Identifier 013-RNLT-LarKK_Page7.jpg
Source Original Manuscript: The mystery of DNA replication by Karl G. Lark.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319368
Reference URL