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Show 222 Diana Thai INTRODUCTION: Obese rodents with brown adipose tissue (BAT) do not develop metabolic syndrome (MetS). Whether BAT is similarly protective against MetS in obese humans is unknown. Studies have shown that BAT is present in some obese individuals. We hypothesized that MetS is less likely to be present in obese people with BAT than in those without BAT. METHODS: We enrolled 30 (13 females) obese (BMI ≥ 30 kg/m², weight<159kg) young adults, ages 18-30y. MetS was defined as the presence of three of the following: elevated blood pressure, waist circumference (WC), fasting glucose, triglycerides, and low high-density lipoprotein choles-terol (HDL-C). The presence of BAT was determined using PET/CT scan performed as follows: par-ticipants were seated in a cool room (16°C) for one-hour, then injected with 18F-FDG and cooled during the 1 hour uptake period. χ2 analysis was used to evaluate the relationship between MetS and BAT. RESULTS: BAT was present in 13 (6 females, 7 males) of the 30 subjects (43.3%). MetS was present in 3 of the 13 with BAT (23.1%) and in 4 of 17 (23.5%) without BAT. (See Table) CONCLUSION: In this relatively small study of obese adults, there was no association between BAT and MetS. Further studies with larger numbers of subjects are required to determine the role of BAT in the development of metabolic dysfunction. THE RELATIONSHIP BETWEEN BROWN ADIPOSE TISSUE AND THE METABOLIC SYNDROME IN OBESE YOUNG ADULTS Diana Thai (Nicole L. Mihalopoulos) Department of Pediatrics/Health Sciences LEAP University of Utah Health sciences leap program spring 2012 Nicole L. Mihalopoulos |