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Show 130 Francesca Nichols school of medicine and health sciences Osteoporotic related fractures are a direct result of the demineralization of bone tissues. When a weight-bearing bone is broken, an implant is typically used to stabilize the fracture site until the bone heals. However, in an osteoporotic patient, these implants may not achieve adequate fixation due to the already decreased bone mineral of the patient. By creating a demineralized bone model that simulates human osteoporotic bone in both bone mineral density (BMD, g/cm2) and mechanical properties, orthopaedic im-plants can be tested in vitro. With this model, the effectiveness and success of these implants can be better determined under demineralized bone conditions. A total of 120 cancellous bone specimens were excised from 30 ovine vertebrae (height: 5.0 mm, diameter: 7.0mm). These bone cores were initially scanned using a pico dual energy x-ray absorptiometry (pDEXA) (Sabre, Norland Medical Systems, Fort Atkinson, WI) machine to determine BMD and bone mineral content (BMC, g). After scanning, the cores were placed in 1 of 5 solutions (0.9% Saline, 0.5 M HCl, 0.5 M EDTA, 0.5 M Formic Acid, Household Vinegar). A total of 12 time points were investigated, ranging from 0 to 144 hours. After demineralization, all cores were scanned again and compressively tested using an Instron load cell (Model 1331 with 8800 fast track controller upgrade, Instron Corp., Canton, MA). Based on the BMD, BMC, and compressive strength of the demineralized bone cores, it was determined that household vinegar would be the best solution to create an osteoporotic bone model due to its rate of demineralization, ease of use, and availability. As this study used ovine vertebrae, future work needs to be completed using a human bone model in order to more closely simulate the mechanical properties of human osteoporotic bone. Once applied to human bone, this model has the potential to personalize medicine for patients with osteoporosis who may require orthopedic implants in the future. IN VITRO DEMINERALIZATION OF BONE TO MODEL CHANGES IN MINERAL DENSITY AND MECHANICAL PROPERTIES DUE TO OSTEOPOROSIS Francesca Nichols (Kent Bachus) Department of Bioengineering University of Utah UNDERGRADUATE RESEARCH ABSTRACTS Kent Bachus |
