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Title Chemical keys to an understanding of life processes
Subject Biochemistry ; Nucleic acids; Proteins
Description Twenty Second Annual Frederick William Reynolds Lecture.
Creator Smith, Emil L., 1911-
Publisher Extension Division, University of Utah
Date 1958-01-13
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,564
Source LD5526.U8 n.s. v.49 no.11
Language eng
Relation Digital reproduction of "Chemical keys to an understanding of life processes," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s6c8277g
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319868
Reference URL

Page Metadata

Title Page18
Description 18 TWENTY-SECOND ANNUAL REYNOLDS LECTURE the formation of more nucleic acid exactly like itself and can also promote the formation of specific virus protein. These are the properties that are generally associated with the genes of multicellular organisms which transmit genetic information from cell to cell. It has also been demonstrated that a strain of a given bacteria can acquire an altered character by adding to it a specific nucleic acid from another strain of the same species. The new characteristic may now be transmitted to daughter cells as inherited information. Again, this is genetic transformation and these transforming factors, as they are called, are nucleic acids. Alteration of the genes to produce inherited mutations can be accomplished by many physical and chemical methods. In each case, those agents which produce mutations can be shown to alter properties of nucleic acids. Thus, several different lines of evidence indicate that genetic information is transmitted by nucleic acids and the result of such transmission is the biosynthesis of specific protein or of an identical nucleic acid. The importance of this concept is far-reaching indeed, both for our understanding of the fundamental properties of living cells and as applied to the study of human disorders. Many types of human metabolic disorders, which are inherited, are now known and an understanding of the molecular basis for some of these disorders has been achieved. As an example, there is a very rare type of inherited disorder in which the individual cannot utilize, in normal manner, a substance called galactose which is a constituent of milk sugar. Very recently, Kalckar and his associates have demonstrated that such individuals do not possess an enzyme which is concerned in the pathway of transformation of galactose to the normal blood sugar, glucose. In this case, the inherited disorder is due to a mutation which somehow prevents or modifies the formation of an essential, normal enzyme. Among the consequences of this disorder are a high incidence of cataract, and damage to the liver and brain, frequently leading to imbecility. The failure to utilize galactose, manifested in a high blood level of galactose, or galactosemia, has grave results and all of this results from the absence of a single enzyme. Fortunately, galactosemia is a rare disorder and fortunate also is the fact that early diagnosis can prevent the consequences of the failure to. utilize galactose. Feeding a diet lacking in milk sugar, the only
Format image/jpeg
Identifier 023-RNLT-SmithE_Page18.jpg
Source Original Manuscript: Chemical keys to an understanding of life processes by Emil L. Smith.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319859
Reference URL