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Title Chemical keys to an understanding of life processes
Subject Biochemistry ; Nucleic acids; Proteins
Description Twenty Second Annual Frederick William Reynolds Lecture.
Creator Smith, Emil L., 1911-
Publisher Extension Division, University of Utah
Date 1958-01-13
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,564
Source LD5526.U8 n.s. v.49 no.11
Language eng
Relation Digital reproduction of "Chemical keys to an understanding of life processes," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s6c8277g
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319868
Reference URL

Page Metadata

Title Page12
Description 12 TWENTY-SECOND ANNUAL REYNOLDS LECTURE In order to appreciate the significance of the determination of the structure of insulin, it is desirable to consider the general problem of protein structure. The large protein molecules consist primarily of compounds called amino acids. Each amino acid contains an amino or NH2 group and a carboxyl or COOH group. An example is alanine which was mentioned before. Each amino acid has the general structure R I H2N-C-COOH I H The various amino acids found in proteins differ from each other in possessing different R groups. There are twenty different amino acids found in proteins. All proteins examined, be they from plants, animals, or microorganisms, contain no more than twenty amino acids, although one or more of these may be lacking in a particular case. It is in the way in which these twenty different amino acids are linked together and in the amount of each amino acid present that proteins vary. Amino acids are linked primarily through the amino group of one amino acid to the carboxyl group of another, as shown in the following structure for two coupled amino acids. R' O H R I I! I I H2N-C-C-N-C-COOH I I H H The structure in boldface represents the linkage of one COOH group to an NH2 group with elimination of water. Such head to tail linkage of amino acid residues can be extended to make very large molecules, by sequences of the same or different amino acids. A relatively small protein such as insulin contains fifty-one amino acid residues. Many of the larger proteins may contain thousands of amino acid residues linked together in the same manner. It should be apparent that possible variations in structure even with only twenty different amino acids are perfectly enormous. It is from the diversity of protein structure that the diversity of protein function is achieved.
Format image/jpeg
Identifier 017-RNLT-SmithE_Page12.jpg
Source Original Manuscript: Chemical keys to an understanding of life processes by Emil L. Smith.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319853
Reference URL