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Title Chemical keys to an understanding of life processes
Subject Biochemistry ; Nucleic acids; Proteins
Description Twenty Second Annual Frederick William Reynolds Lecture.
Creator Smith, Emil L., 1911-
Publisher Extension Division, University of Utah
Date 1958-01-13
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier http://content.lib.utah.edu/u?/reynolds,564
Source LD5526.U8 n.s. v.49 no.11
Language eng
Relation Digital reproduction of "Chemical keys to an understanding of life processes," J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s6c8277g
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319868
Reference URL https://collections.lib.utah.edu/ark:/87278/s6c8277g

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Title Page15
Description CHEMICAL KEYS TO AN UNDERSTANDING OF LIFE PROCESSES 15 Thr) Ala)C'w _ ^Sef! Ser] SeO ' @©©©©©©©©©^ © Q ©5%)©©©@@@@@g^@©©©%©(i Figure 2. Tentative amino acid sequence of bovine ribonuclease. The position of the residues in heavy lettering is definitely established. In other sequences, in light lettering, the precise order of the residues remains to be established. From C. B. Anfinsen, Jr., "Structural Basis of Ribonuclease Activity," in Federation Proceedings, 16, 782-791, 1957. can give only partial answers at present. Chemically reactive groups of certain amino acid residues are of key importance in certain enzymes. Moreover, the sequence of certain amino acids and of nearby sequences appears to be of critical importance. During the past few years we have also learned that only a small part of the whole enzyme molecule may be critically concerned in its function. This has been accomplished by various methods, mainly by using certain enzymes to degrade other enzymes. In our laboratory we have been studying an enzyme called papain, which is obtained from the papaya plant. Dr. Hill and I were able to show that of the one hundred eighty amino acid residues present in the papain molecule, approximately two-thirds of the residues could be removed without altering the enzymic specificity or activity of the resulting fragments. Similar work has been accomplished in other laboratories also showing that intact protein structure is not essential for enzyme activity. The importance of these studies is twofold. On the one hand they simplify, to some extent, the experimental problem of studying
Format image/jpeg
Identifier 020-RNLT-SmithE_Page15.jpg
Source Original Manuscript: Chemical keys to an understanding of life processes by Emil L. Smith.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319856
Reference URL https://collections.lib.utah.edu/ark:/87278/s6c8277g/319856