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Title Exploring human heredity
Subject Heredity, Human; Medical genetics; Adaptation (Biology)
Description Twentieth Annual Frederick William Reynolds Lecture.
Creator Stephens, Fayette Ellsworth, 1890-
Publisher Extension Division, University of Utah
Date 1956-01-16
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,362
Source LD5526 .U8 n.s. v.47 no.11
Language eng
Relation Digital reproduction of "Exploring human heredity" J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s64q7rxv
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319670
Reference URL

Page Metadata

Title Page29
Description EXPLORING HUMAN HEREDITY 29 have been made by Dr. Charles M. Woolf. Several hundred death certificates were secured of people who had died of cancer of the breast. The frequency of this same type of cancer among their close relatives was then compared with the frequency of breast cancer in the general population or in a suitable control group. This was repeated for cancer of the stomach. In each instance there was a significant increase in the frequency of the particular type of cancer in question among close relatives as compared with the general population or with the control. There was no significant increase, however, in the frequency of cancers other than the type studied. This was interpreted to mean that there was some hereditary basis for these particular types of cancer, but not for cancer in general. The fact that these significant frequencies were only a little over twice as great as those found in the controls and in the general population added weight to the multiple factor explanation for the production of cancer. Twin studies have shown that environmental factors are also important. It is a common thing to hear of cancer families where cancer of the stomach, cancer of the breast, or other types of cancer seem to be concentrated in some particular family or kindred. Is this hereditary or is it due to chance alone? When the frequency of a given type of cancer is high in the general population, chance alone could account for several cases of it occasionally occurring in the same family, just as families of all boys or families of all girls occur. In order to investigate this problem further, pedigree studies of several kindreds have been made in our laboratory where a concentration of one of these common types of cancer was found in a family. In no case has evidence of a single gene inheritance been found. In generations following the generation where the concentration of cancer occurred in a family, the defect seemed to disappear, suggesting multiple factor inheritance. A precancerous condition in a few rare types of cancer seems to be due to single gene inheritance. An example of this is intestinal polyposis. This condition is characterized by many small polyps, or mushroom-like growths, developing in the large intestine. If not removed by surgery, some of these may develop into cancer. Two different kindreds showing this trait have been studied in our laboratory by Dr. Eldon J. Gardner and Dr. Ralph C. Richards. In the first kindred, polyposis was inherited as a dominant trait. The
Format image/jpeg
Identifier 029-RNLT-StephensF_Page29.jpg
Source Original Manuscript:Exploring human heredity by Fayette E. Stephens.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319663
Reference URL