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Title Exploring human heredity
Subject Heredity, Human; Medical genetics; Adaptation (Biology)
Description Twentieth Annual Frederick William Reynolds Lecture.
Creator Stephens, Fayette Ellsworth, 1890-
Publisher Extension Division, University of Utah
Date 1956-01-16
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier http://content.lib.utah.edu/u?/reynolds,362
Source LD5526 .U8 n.s. v.47 no.11
Language eng
Relation Digital reproduction of "Exploring human heredity" J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s64q7rxv
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319670
Reference URL https://collections.lib.utah.edu/ark:/87278/s64q7rxv

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Title Page13
Description EXPLORING HUMAN HEREDITY 13 the trait, and it occurs as often in one sex as the other. From this it appears that this trait is inherited as a simple Mendelian dominant. By this we mean that if the gene for Achondroplasia and the normal gene were both present the individual would show Achondroplasia. The normal gene in this case is recessive and cannot be expressed in the presence of the dominant gene. There is no way of telling whether or not dominance is complete, since in no instance did two affected individuals marry so that a homozygous, or true breeding, person could be produced. The first affected individual must have resulted from a mutation. Neither of his parents were affected, nor did the trait occur in other branches of the kindred. The explanation is that occasionally something happens to a gene which changes it so that it no longer behaves the same. It now has a different effect, and from here on it is produced in the modified form. This we call a gene mutation. It has been possible to induce artificial mutations by the use of radiation or of certain chemicals. Just how they occur in nature, however, is not as yet understood. This Achondroplasia kindred is especially interesting because we are able to follow the trait from the time it first occurred as a mutation. From this pedigree chart we are able to see just how it has spread in a definite unit of the population. As a result of this study we can give valuable information to the members of this kindred regarding the chances of their transmitting the trait. Each affected person who marries a normal individual has a one-half chance of transmitting the trait to any child he might have. A non-affected person, on the other hand, who marries a normal individual will not transmit the trait nor will it occur in later generations because of his ancestry. Even though he had an affected father or mother and numerous affected relatives, he drew the normal gene instead of the defective one and therefore cannot pass on the defect. Many times this type of assurance is just as valuable as information on the chances of affected persons transmitting a trait. A man and his wife came to our laboratory to inquire about the inheritance of a certain dominant trait. They finally narrowed their questions down to a specific kindred and finally to a certain young man in the kindred. They first wanted to know if he had the trait. One of his parents and several of his brothers and sisters and relatives were affected, but he was not. Twice he had been examined by a physician
Format image/jpeg
Identifier 013-RNLT-StephensF_Page13.jpg
Source Original Manuscript:Exploring human heredity by Fayette E. Stephens.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319647
Reference URL https://collections.lib.utah.edu/ark:/87278/s64q7rxv/319647