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Title Exploring human heredity
Subject Heredity, Human; Medical genetics; Adaptation (Biology)
Description Twentieth Annual Frederick William Reynolds Lecture.
Creator Stephens, Fayette Ellsworth, 1890-
Publisher Extension Division, University of Utah
Date 1956-01-16
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier,362
Source LD5526 .U8 n.s. v.47 no.11
Language eng
Relation Digital reproduction of "Exploring human heredity" J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s64q7rxv
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319670
Reference URL

Page Metadata

Title Page25
Description EXPLORING HUMAN HEREDITY 25 at the time of birth; others develop in childhood, and still others do not develop until later in life. The time of expression is very important because of the different way in which the life of an individual is affected. If hereditary nerve deafness occurs very early in the life of a child, he becomes a deaf-mute and learns to talk with great difficulty, but if the deafness is delayed until the person is 25 or 30 years of age the effect is quite different. His education is usually not interfered with and he finds his place in society without being materially handicapped. In a case of this kind it is sometimes valuable to be able to know at an earlier age if a person will later develop deafness. This is especially true if a person is apt to go into a profession where deafness might be a serious handicap. A large kindred showing nerve deafness has been studied in our laboratory in cooperation with Dr. David Dolowitz. Deafness in this kindred usually begins in the early twenties anci progresses until hearing aids are essential. Complete loss of hearing does not occur. Physical examinations and audiometer tests have been made on members of the kindred in an attempt to determine the pattern of inheritance and to discover, if possible, a method of identifying at an early age those individuals who would later develop the trait. Figure 11 shows a pedigree history of the kindred. From this a clear pattern of dominant inheritance is indicated. Five years after the first tests were made, repeat tests were started, particularly of individuals who were young at the time of the original examination. This was done to try to discover a means to identify persons who would later become deaf before they themselves were aware of any defect in their hearing. These studies are continuing. Another way in which genes may affect the body is by producing susceptibility or resistance to certain diseases. Figure 12 shows a kindred where certain individuals are susceptible to Pyelonephritis, a bacterial infection of the kidneys. The disease is fatal in the males. Twelve male members of this kindred have died as a result of this disease. The malady progresses until affected individuals become deaf and finally die of uremic poisoning. This susceptibility is gene-determined, but just why the gene makes the kidneys susceptible is not known. Post mortem examinations have shown no abnormal physical structure which might account for it. This trait traces back to one of the wives of 1-1. The other wife was her sister. Both had large families, but only in the line of the first wife was this trait found.
Format image/jpeg
Identifier 025-RNLT-StephensF_Page25.jpg
Source Original Manuscript:Exploring human heredity by Fayette E. Stephens.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319659
Reference URL