Page21

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Title Exploring human heredity
Subject Heredity, Human; Medical genetics; Adaptation (Biology)
Description Twentieth Annual Frederick William Reynolds Lecture.
Creator Stephens, Fayette Ellsworth, 1890-
Publisher Extension Division, University of Utah
Date 1956-01-16
Date Digital 2008-05-29
Type Text
Format image/jpeg
Digitization Specifications Original scanned on Epson Expression 10000XL flatbed scanner and saved as 400 ppi uncompressed tiff. Display images generated in PhotoshopCS and uploaded into CONTENTdm Aquisition Station.
Resource Identifier http://content.lib.utah.edu/u?/reynolds,362
Source LD5526 .U8 n.s. v.47 no.11
Language eng
Relation Digital reproduction of "Exploring human heredity" J. Willard Marriott Library Special Collections
Rights Digital Image Copyright University of Utah
Metadata Cataloger Seungkeol Choe; Ken Rockwell
ARK ark:/87278/s64q7rxv
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-31
ID 319670
Reference URL https://collections.lib.utah.edu/ark:/87278/s64q7rxv

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Title Page21
Description EXPLORING HUMAN HEREDITY 21 The second type, or childhood muscular dystrophy, is the most severe of all the forms. It occurs in early childhood and affects only males. They seldom live past the age of thirty years and are totally incapacitated. The disease is inherited as a sex-linked recessive and is transmitted only by the females. In order for a female to show a sex-linked recessive trait herself, her father must be affected and her mother must be at least a carrier. Affected males never reproduce ; females are not affected, but may be carriers. Figure 8 shows an eleven-year-old boy with this disease. These types represent two different genes, each one producing muscular dystrophy but in different forms. The type of inheritance is understood, but it is not yet known how the genes do their work. It is generally thought by geneticists that these defective genes originate as mutations. Some work has been done to estimate frequency with which human mutations occur. We did this in our study of childhood muscular dystrophy. Forty-three kindreds showing this trait were studied. In no case did an affected individual marry and have children. If this were to continue over a long period of time, natural selection would gradually eliminate the trait unless new members were supplied from some other source. There was no evidence, however, that the frequency of this form of dystrophy had changed during the past several years. Pedigree studies were next made to see if there was any evidence of mutations in any of the kindreds. In some, only one dystrophic individual was found. If it were due to a sex-linked recessive gene it must have been transmitted through the female line from the first known female in the line. In many of these kindreds there were so many males in the line that chance would rule out the transmission from the first known female. It was con-
Format image/jpeg
Identifier 021-RNLT-StephensF_Page21.jpg
Source Original Manuscript:Exploring human heredity by Fayette E. Stephens.
Setname uu_fwrl
Date Created 2008-07-29
Date Modified 2008-07-29
ID 319655
Reference URL https://collections.lib.utah.edu/ark:/87278/s64q7rxv/319655