| Title |
Anterior Ischemic Optic Neuropathy and Activated Protein C Resistance |
| Creator |
Worrall, BB; Moazami, G; Odel, JG; Behrens, MM |
| Affiliation |
Department of Neurology, Columbia Presbyterian Medical Center, New York, New York 10032-2603, USA. |
| Abstract |
Nonarteritic anterior ischemic optic neuropathy (AION) is a well-described entity that is believed to be caused by abnormal anatomy of the optic disc and to be precipitated by several stressors or disease states. Activated protein C resistance (APCR) is a recently described mutation of factor V (FV) gene that renders FV resistant to cleavage by activated protein C. APCR predisposes to thrombotic events. The case of a 61-year-old woman with AION and activated protein C resistance is presented, and the management is discussed. We thoroughly review the literature on these two conditions. We propose that a prospective analysis of the potential role of APCR in some cases of AION is needed and suggest that physicians consider this and other prothrombotic states when evaluating patients with AION. |
| Subject |
Factor V/genetics; Female; Humans; Middle Older people; Optic Disk/blood supply; Optic Neuropathy, Ischemic/complications; Optic Neuropathy, Ischemic/metabolism; Optic Neuropathy, Ischemic/physiopathology; Partial Thromboplastin Time; Protein C/metabolism; Thrombosis/complications; Thrombosis/metabolism; Thrombosis/physiopathology |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
224826 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6962pmg/224826 |
