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High-Titer CRMP-5 Paraneoplastic Optic Neuropathy as the Only Clinical Manifestations in a Patient with Small Cell Lung Carcinoma
| Title | Journal of Neuro-Ophthalmology, March 2008, Volume 28, Issue 1 |
| Date | 2008-03 |
| Language | eng |
| Format | application/pdf |
| Type | Text |
| Publication Type | Journal Article |
| Collection | Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher | Lippincott, Williams & Wilkins |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management | © North American Neuro-Ophthalmology Society |
| ARK | ark:/87278/s6vt4z6b |
| Setname | ehsl_novel_jno |
| ID | 225680 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6vt4z6b |
Page Metadata
| Title | High-Titer CRMP-5 Paraneoplastic Optic Neuropathy as the Only Clinical Manifestations in a Patient with Small Cell Lung Carcinoma |
| Creator | Margolin, E; Flint, A; Trobe, JD |
| Affiliation | Department of Ophthalmology , Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA. |
| Abstract | Paraneoplastic optic neuropathy (PON) is a rare syndrome usually associated with small cell lung carcinoma. In the 27 rigorously reported cases, neurologic manifestations other than visual loss have been present in all but 2. In the single case in which vision improved in response to treatment of the cancer, the collapsin response-mediating protein (CRMP)-5 titer did not change, and the ophthalmic examination was not detailed. We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of PON marked by an extremely high titer of CRMP-5 antibody. Treatment of the underlying small cell lung cancer coincided with resolution of the visual abnormalities and a dramatic decrease in the CRMP-5 titer. |
| Subject | Older people; Antineoplastic Combined Chemotherapy Protocols, therapeutic use; Carcinoma, Small Cell, complications; Carcinoma, Small Cell, radiotherapy; Female; Humans; Lung, pathology; Lung Neoplasms, complications; Lung Neoplasms, radiotherapy; Lymph Nodes, pathology; Nerve Tissue Proteins, analysis; Nerve Tissue Proteins, blood; Neural Cell Adhesion Molecules, analysis; Neural Cell Adhesion Molecules, metabolism; Optic Disk, immunology; Optic Disk, pathology; Optic Disk, physiopathology; Optic Nerve Diseases, blood; Optic Nerve Diseases, immunology; Optic Nerve Diseases, pathology; Paraneoplastic Syndromes, Nervous System, blood; Paraneoplastic Syndromes, Nervous System, pathology; Paraneoplastic Syndromes, Nervous System, physiopathology; Radiotherapy; Retinal Artery, immunology; Retinal Artery, pathology; Retinal Artery, physiopathology; Tomography, X-Ray Computed; Treatment Outcome; Tumor Markers, Biological, analysis; Tumor Markers, Biological, blood; Tumor Markers, Biological, immunology; Up-Regulation, drug effects; Up-Regulation, immunology; Vision, Low, blood; Vision, Low, immunology; Vision, Low, pathology; Vitreous Body, immunology; Vitreous Body, pathology; Vitreous Body, physiopathology |
| Format | application/pdf |
| Publication Type | Journal Article |
| Collection | Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher | Lippincott, Williams & Wilkins |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management | © North American Neuro-Ophthalmology Society |
| Setname | ehsl_novel_jno |
| ID | 225664 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6vt4z6b/225664 |