| Title |
Long-Term Survival in Paraneoplastic Opsoclonus-Myoclonus Syndrome Associated with Small Cell Lung Cancer |
| Creator |
Hassan, KA; Kalemkerian, GP; Trobe, JD |
| Affiliation |
Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA. |
| Abstract |
Paraneoplastic opsoclonus-myoclonus syndrome (OMS) is associated with small cell lung cancer (SCLC) in adults. Without appropriate treatment for SCLC, all reported patients with SCLC and OMS have died of complications of OMS within 3 months of diagnosis. With appropriate treatment, about half of reported patients have had improvement in neurologic function, and several have become long-term survivors (6-84 months). We report a patient with SCLC who presented with OMS and was refractory to immunosuppressive therapy but responded rapidly to antineoplastic therapy and remains alive with no sign of SCLC recurrence and minimal residual neurologic deficits 30 months after diagnosis. In patients presenting with OMS, early recognition and treatment of the underlying malignancy probably improve the chances for recovery from the OMS with minimal deficit and ultimate survival. |
| Subject |
Antineoplastic Combined Chemotherapy Protocols, therapeutic use; Brain, drug effects; Brain, immunology; Brain, physiopathology; Carcinoma, Small Cell, complications; Carcinoma, Small Cell, physiopathology; Carcinoma, Small Cell, therapy; Disease Progression; Female; Humans; Immunoglobulins, Intravenous, therapeutic use; Immunosuppressive Agents, therapeutic use; Lung, pathology; Lung, radiography; Lung Neoplasms, complications; Lung Neoplasms, physiopathology; Lung Neoplasms, therapy; Middle Older people; Opsoclonus-Myoclonus Syndrome, diagnosis; Opsoclonus-Myoclonus Syndrome, physiopathology; Opsoclonus-Myoclonus Syndrome, therapy; Paraneoplastic Syndromes, Nervous System, diagnosis; Paraneoplastic Syndromes, Nervous System, physiopathology; Paraneoplastic Syndromes, Nervous System, therapy; Radiotherapy; Steroids, therapeutic use; Survivors; Tomography, X-Ray Computed; Treatment Outcome |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225666 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vt4z6b/225666 |
