Improvement in Visual Fields in a Patient with Melanoma-Associated Retinopathy Treated with Intravenous Immunoglobulin

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Title Journal of Neuro-Ophthalmology, March 2008, Volume 28, Issue 1
Date 2008-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6vt4z6b
Setname ehsl_novel_jno
ID 225680
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vt4z6b

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Title Improvement in Visual Fields in a Patient with Melanoma-Associated Retinopathy Treated with Intravenous Immunoglobulin
Creator Subhadra, C; Dudek, AZ; Rath, PP; Lee, MS
Affiliation Division of Hematology, Oncology, and Transplantation (CS, AZD), University of Minnesota, Minneapolis, Minnesota 55455, USA.
Abstract Melanoma-associated retinopathy (MAR) is a rare disorder characterized by photopsias, shimmering vision, nyctalopia, and dysfunction of rod photoreceptor cells. We describe a 56-year-old man with metastatic cutaneous melanoma to the lymph nodes and MAR. He underwent resection of the metastasis followed by radiation therapy. Over the ensuing 2 months, visual function worsened so he was treated with intravenous immunoglobulin (IVIg). Visual fields, but not electroretinography, improved steadily over the next year. No evidence of recurrence or metastatic disease has been found. Our patient indicates that even after a reduction or elimination of melanoma tumor burden and presumably the attenuation of the antigenic stimulus driving MAR, this disorder can continue to progress. In this setting, IVIg therapy should be considered a viable treatment option.
Subject Autoantibodies, drug effects; Autoantibodies, immunology; Disease Progression; Electroretinography; Humans; Immunoglobulins, Intravenous, administration & dosage; Immunotherapy, methods; Lymph Nodes, pathology; Lymph Nodes, surgery; Male; Melanoma, complications; Melanoma, immunology; Middle Older people; Neck Dissection; Neoplasm Recurrence, Local, radiotherapy; Neoplasm Recurrence, Local, surgery; Paraneoplastic Syndromes, Nervous System, drug therapy; Paraneoplastic Syndromes, Nervous System, immunology; Paraneoplastic Syndromes, Nervous System, physiopathology; Radiotherapy; Retina, drug effects; Retina, immunology; Retina, physiopathology; Retinal Bipolar Cells, drug effects; Retinal Bipolar Cells, immunology; Retinal Bipolar Cells, pathology; Retinal Diseases, drug therapy; Retinal Diseases, immunology; Retinal Diseases, physiopathology; Treatment Outcome; Vision, Low, drug therapy; Vision, Low, immunology; Vision, Low, physiopathology; Visual Fields, drug effects; Visual Fields, immunology
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225665
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vt4z6b/225665