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Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer Thickness in NMO Patients

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Title Journal of Neuro-Ophthalmology, September 2013, Volume 33, Issue 3
Date 2013-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6gr03wb
Setname ehsl_novel_jno
ID 227503
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gr03wb

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Title Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer Thickness in NMO Patients
Creator Lange, Alex P; Sadjadi, Reza; Zhu, Feng; Alkabie, Samir; Costello, Fiona; Traboulsee, Anthony L
Affiliation Neuro-Ophthalmology, Department of Ophthalmology (APL), University of British Columbia, British Columbia, Canada; Department of Medicine (RS, FZ, SA, ALT), Division of Neurology, University of British Columbia, British Columbia, Canada; Departments of Clinical Neurosciences and Surgery (FC), University of Calgary, Hotchkiss Brain Institute, Alberta, Canada; and Vista Klinik (APL), Vista Diagnostics and Laser Vista, Binnigen, Switzerland
Abstract Neuromyelitis optica (NMO) is a demyelinating syndrome of the central nervous system. NMO might be underdiagnosed at early stages when patients have not yet developed the full spectrum of disease. The aim of this study was to analyze the retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) and to compare RNFL measurements between NMO patients, patients with relapsing-remitting multiple sclerosis (RRMS), and healthy controls to determine whether differences in RNFL thickness could be an early diagnostic marker for NMO. In a cross-sectional study, eyes of 25 NMO patients, 25 RRMS patients, and 50 healthy controls underwent RNFL measurements by OCT. Clinical parameters were collected by history and chart review. Pairwise Wilcoxon rank sum tests with Holm correction were used to compare means of RNFL thickness among 6 groups (NMO, RRMS, and healthy control) of patients [without or with 1 or more episode of optic neuritis (ON)]. The association between RNFL thickness and patient characteristics for NMO group was examined via linear mixed-effects models (adjusting for within-patient intereye correlations and history of ON, where appropriate). Based on the pairwise Wilcoxon rank sum tests with Holm correction, significant differences were found between NMO with 1 episode of ON and non-ON eyes (mean RNFL 63.7 vs 97.0 m, P < 0.0001), multiple sclerosis (MS) non-ON eyes, and controls (RNFL 93.2 vs 98.4 m, P = 0.03). No significant differences were found between NMO and MS with 1 attack of ON eyes (RNFL 63.7 vs 73.9 m, P = 0.46), NMO non-ON eyes and healthy controls (RNFL 97.0 vs 98.4 m, P = 0.56), and NMO non-ON and MS non-ON (RNFL 97.0 vs 93.2 m, P = 0.56). For NMO group, RNFL thickness was associated with a history of ON (P < 0.001) but not with disability or disease duration when adjusting for the history of ON (P > 0.1). RNFL in NMO is not different enough to distinguish NMO ON from MS ON eyes, but the intereye difference in RFNL with a history of unilateral ON may be a better diagnostic marker for NMO.
Subject Adult; Older people; Cross-Sectional Studies; Diagnosis, Differential; Female; Humans; Male; Middle Older people; Multiple Sclerosis, Relapsing-Remitting; Neuromyelitis Optica; Optic Neuritis; Retina; Retinal Ganglion Cells; Tomography, Optical Coherence
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227473
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gr03wb/227473
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