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A Resting State Functional Magnetic Resonance Imaging Study of Patients With Benign Essential Blepharospasm

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Title Journal of Neuro-Ophthalmology, September 2013, Volume 33, Issue 3
Date 2013-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6gr03wb
Setname ehsl_novel_jno
ID 227503
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gr03wb

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Title A Resting State Functional Magnetic Resonance Imaging Study of Patients With Benign Essential Blepharospasm
Creator Zhou, Bo; Wang, Jinyu; Huang, Yulan; Yang, Yousong; Gong, Qiyong; Zhou, Dong
Affiliation Department of Neurology (BZ, JW, YH, YY), Sichuan Provincial People's Hospital, Chengdu, China; and Departments of Neurology (DZ) Radiology (QG), West China Hospital, Sichuan University, Chengdu, China
Abstract Benign essential blepharospasm (BEB) is a neurologic disorder characterized by an adult-onset focal dystonia that causes involuntary blinking and eyelid spasms. The pathophysiology of BEB patients remains unclear. This study investigated intrinsic low-frequency fluctuation in BEB patients during resting state functional magnetic resonance imaging (fMRI). The study included 9 patients with BEB (mean age, 61.7 years; range, 52-66 years), in whom the average duration of symptoms was 2.7 1.8 years, and another 9 subjects from an age- and sex-matched control group. Resting state fMRI was performed in both the patients with BEB and the normal controls. Voxel-based analysis was used to characterize the alteration of amplitude of low-frequency fluctuation (ALFF) in both patients with BEB and the normal controls. The whole brain analysis indicated that in comparison with the normal control group, there was a significantly increased ALFF in the left putamen, pallidum, insular lobe, and medial prefrontal cortex and a significantly decreased ALFF in the bilateral somatosensory regions, thalami, cerebellum, and medial and posterior cingulate cortex. The present study suggests that both an abnormal default mode network and corticostriatopallidothalamic loop may play a role in the pathophysiology of BEB.
Subject Older people; Blepharospasm; Brain; Brain Mapping; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Middle Older people
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Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227477
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gr03wb/227477
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