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Show The Role of DNA Repair Enzymes in Cancer Prevention H, H*pn rtraent of Chemistry U [ih:er*itv nf Utah ' kin. tid (DNA) is a molecule foumi in every cell tiie codes for making proteins $&& directing cellular reproduction. All of the infomiatioii m DNA is stored using combinarions of lour bases, Tl^c fotir bases arc cytostne (C), tfeyniine (T1)- gua3iinc (G), and ad cum e (A). When ihese bases are d^n^g^d, m incoir^cJ base can pair with the mutated base, Jhu.s altering ftic genetic code. If Ihe DNA is altered the results to the ce!l can be very bar milt I and lead to diseases such as cancer. Ail cells nut si therefore have repair enzymes lhat can correct the mu far ion before if is p^sseti on to IxtJure cells, The.se enzvutas must recognize and repair different \\rnm ol damage. One common modification that can lead to mut&lioEi t^ccurs u-lien guanine is oxidized to form S-oxo-guanine (OG). Several repaii- oiiMnes can coii^cl this inutanon, uicludmg Fpg, UCX}G1, ^d yOGG2, Thes^ enzymes ^-e ^^uiied u^ing different type.sof radioaetivekinetic cleavage assays. 51 |