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Show E)isabct:i Temporal Neuronal Development of the Nematudt: C. Elegans s M, rniuHt uf Biolugy, Lni vtrsity fjf ("tali Tiie nematode C, elegans comprises a simplified nei\x>us systeiiL witli all 302 neurons accounted for at time and position of growth and at adult eomiocriviry. These worms are trfiusparoEit, and their GABAorgic neurons can be iluroesced using GFP to ideiuify neuronal promoters, Though most of these neurons have been characterized, rhoro is no complete temporal map for their development through the embryo to adult stages of the worm. The unc-199 gene has been found to st4bi!i?_e the structure of the nervous system in C elegans. A suppressor screen of the UNC-119 protein in the unknown signaling pathway reveals the otherwise imobservable characteristics of the recessive phenotype* By SNP mapping, it is possible to pinpoint the DNA sequence of the various inn tan t phenotypes associated with unc-119, (Knobel et al; 2001) 38 |