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Show 132 LITERATURE ABSTRACTS A lO- year- old girl with Sjogren's syndrome ( diagnosis from a parotid biopsy) presented with central nervous system symptoms and a complaint of decreased vision. Visual acuity left eye was 20/ 200 with nerve fiber layer dropout and temporal pallor of the disc on fundus examination. Magnetic resonance imaging of the brain showed multiple infarcts. With immunosuppressive therapy, her vision improved. Lyn A. Sedwick, M. D. Familial Trigeminal Anesthesia. Keys CL, Sugar J, Mafee MF. Arch OphthalmoI1990; 108: 1720- 3 ( Dec). [ Reprint requests to Dr. J. Sugar, Department of Ophthalmology, VIC Eye Center, University of Illinois at Chicago College of Medicine, 1855 W. Taylor Street, Chicago, IL 60612.] A father and two sons had bilateral recurrent corneal ulcers. Hypoplastic trigeminal nerves were found on magnetic resonance imaging of the father. A number of other family members were examined, but none had corneal anesthesia or ulceration. This led to the hypothesis that this represented a new autosomal dominant mutation in the father. Lyn A. Sedwick, M. D. Herpes Zoster Optic Neuritis in Human Immunodeficiency Virus Infection. Arch Ophthalmol 1990; 108: 782- 3 ( June). [ No reprint information given.] ~ 40- year- old HIV- positive woman developed a ~ esIcu~ ar ~ as~ on the right and then the left trigemmal dIstributIon and developed visual loss with periphlebitis and an edematous optic nerve. All investigation for any other logical infection besides herpes zoster was negative. Her vision did not improve on an aggressive acyclovir and intravenous methylprednisone therapy. Lyn A. Sedwick, M. D. Septo- Optic Dysplasia in Two Siblings. Benner JD, Preslan MW, Gratz E, Joslyn J, Schwartz M, Kelman S. Am J Ophthalmol 1990; 109: 632- 7 Oune~. JClift Neuro- ophthalmol. Vol. 11. No. c. 1991 [ Reprint requests to Dr. M. W. Preslan, Department of Ophthalmology, University of Maryland Hospital, 22 S. Greene Street, Baltimore, MD 21201.] The authors describe two siblings with septooptic dysplasia which they postulate to have occurred by autosomal- recessive inheritance. Lyn A. Sedwick, M. D. Variable Genotype of Leber's Hereditary Optic Neuropathy Patients. Lott MT, Alexander SV, Wallace DC. Am J Ophthalmol 1990; 109: 625- 31 ( June). [ Reprint requests to Dr. D. Wallace, Emory University School of Medicine, Department of Biochemistry, 3031 Rollins Research Center, Atlanta, GA 30329.] Mitochondria and Leber's Hereditary Optic Neuropathy. Newman NJ, Wallace DC. Am JOphthalmol 1990; 109: 726- 9 ( June). [ Reprint requests to Dr. N. Newman, Neuro- ophthalmology, Emory Eye Center, 1327 Clifton Road, N. E., Atlanta, GA 30322.] The authors examined blood and hair samples from patients with Leber's optic neuropathy and their relatives for mitochondrial DNA populations. They found differing proportions of wild type versus mutant mitochondrial DNA in different family members and in different tissues of the same individuals. They discussed the significance of their findings. Drs. Nancy J. Newman and Douglas Wallace discuss this article in an editorial in the same issue. Lyn A. Sedwick, M. D. Neuro- Ophthalmologic Manifestations of Lyme Disease. Lesser RL, Kornmehl EW, Pachner AR, Kattah J, Hedges TR III, Newman NM, Ecker PA, Glassman ML Ophthalmology 1990; 97: 699- 706 ( June). [ Reprint requests to Dr. R. L. Lesser, Yale University School of Medicine, Department of Ophthalmology and Visual Science, 333 Cedar Street, New Haven, CT 06510.] The authors present six patients with neuroophthalmic manifestations of Lyme disease, in- |
