Evolving Concepts in the Pathogenesis of Multiple Sclerosis and their Therapeutic Implications

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Title Journal of Neuro-Ophthalmology, December 2001, Volume 21, Issue 4
Publisher Lippincott, Williams & Wilkins
Date 2001-12
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6md254v
Setname ehsl_novel_jno
Date Created 2008-10-25
Date Modified 2020-03-03
ID 225101
Reference URL https://collections.lib.utah.edu/ark:/87278/s6md254v

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Title Evolving Concepts in the Pathogenesis of Multiple Sclerosis and their Therapeutic Implications
Creator Rudick, RA
Affiliation Mellen Center for Multiple Sclerosis Treatment and Research Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Subject Adjuvants, Immunologic/therapeutic use; Humans; Interferon-beta/therapeutic use; Magnetic Resonance Imaging; Multiple Sclerosis/drug therapy/etiology; Recurrence
Abstract Recent evidence suggests that multiple sclerosis (MS) is a continuously active neuropathologic process, even during the subclinical relapsing/remitting phase of the disease. Patients commonly feel well and function without disability for many years, experiencing only occasional relapses and nondisabling symptoms. In time, many evolve into a pattern of continuously progressive neurologic disability termed secondary progressive MS (SP-MS). SP-MS is hypothesized to occur once disease severity has exceeded a threshold. Above that threshold, compensatory mechanisms are inadequate to maintain normal function, and further disease progression is accompanied by progressively worsening disability. Inflammation dominates the early stage of disease. Progressive axonal pathology may underlie clinical disease progression in later stages. These concepts have important implications related to the diagnosis, methods for patient follow-up, type and timing of disease therapy, and the testing of neuroprotective drugs in MS.
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Setname ehsl_novel_jno
Date Created 2008-10-25
Date Modified 2021-05-06
ID 225089
Reference URL https://collections.lib.utah.edu/ark:/87278/s6md254v/225089