Journal of Neuro-Ophthalmology, December 2001, Volume 21, Issue 4

Table of Contents

JOURNAL OF Neuro- Ophthalmology The Official Journal of the North American Neuro- Ophthalmology Society VOLUME 21, NUMBER 4/ NOVEMBER 2001 Contents Editorial 237 Treat Early, but Treat Hard: Interferon- P Dose Makes A Difference Daniel D. Mikol Original Contributions 240 Optic Disc Topography in Pseudopapilledema: A Comparison to Pseudotumor Cerebri Gary L. Trick, Sonali S. Bhatt, David Dahl, and Barry Skarf 245 Polarimetric Nerve Fiber Analysis in Patients with Visible Optic Nerve Head Drusen Sinan Tatlipinar, Sibel Kadayifcilar, Banu Bozkurt, Sansal Gedik, Ergun Karaagaoglu, Mehmet Orhan, and Murat Irkec 250 Vertical Saccades in Superior Oblique Palsy and Brown's Syndrome Jason J. S. Barton and James M. Intriligator 256 Patterns of Extraocular Muscle Weakness in Vasculopathic Pupil- Sparing, Incomplete Third Nerve Palsy Scott Sanders, Aki Kawasaki, and Valerie A. Purvin 260 Catastrophic Antiphospholipid Antibody Syndrome Manifesting as an Orbital Ischemic Syndrome Michael S. Vaphiades, Wade Brock, Harry H. Brown, Gissur Petursson, and Christopher T. Westfall ( continued on next page) Listed in Index Medicus/ MEDLINE, Current Contents/ Clinical Medicine, SCISEARCH, Biomedical Database, Ocular Resources Review, and in Automatic Subject Citation Alert; listed and abstracted in Ophthalmic Literature and in Stroke. Journal of Neuro- Ophthalmology ( ISSN: # 1070- 8022), is published quarterly in March, June, September, and December by Lippincott Williams & Wilkins, at 16522 Hunters Green Parkway, Hagerstown, MD 21740- 2116. Business and production offices are located at 530 Walnut Street, Philadelphia, PA 19106- 3621. Periodicals postage paid at Hagerstown, MD and at additional mailing offices. Copyright © 2001 by Lippincott Williams & Wilkins, Inc. Address for subscription information, orders or change of address: ( except Japan, India, Bangladesh, Sri Lanka, Nepal, and Pakistan) 16522 Hunters Green Parkway, Hagerstown, MD 21740- 2116; phone: [phone]; fax: [phone]; in Maryland, call collect 301- 223- 2300. In Japan, contact LWW Igaku- Shoin Ltd., 3- 23- 14 Hongo, Bunkyo- ku, Tokyo 113- 0033, Japan; phone: [phone]; fax: [phone]. In India, Bangladesh, Sri Lanka, Nepal, and Pakistan, contact Globe Publication Pvt. Ltd. B- 13, 3rd FL, A Block, Shopping Complex, Naraina Vihar, Ring Road, New Delhi 110028, India; phone: [phone]; fax: [phone]. Annual subscription rates worldwide: $ 238.00 Individual Domestic, $ 279.00 Individual International, $ 377.00 Institutional Domestic, $ 432.00 Institutional International, $ 112.00 Students/ Residents Domestic, $ 112.00 Students/ Residents International. ( The Canadian GST Tax of 7% will be added to the subscription price of all orders shipped to Canada. Lippincott Williams & Wilkins' GST Identification Number is 895524239. Publications Mail Agreement # 617636.) Subscriptions outside the United States must be prepaid. Subscriptions outside North America must add $ 3.00 for airfreight delivery. Price subject to change without notice. Copies will be replaced without charge if the publisher receives a request within 90 days of the mailing date, both in the U. S. and worldwide. Visit us online at www. lww. com. POSTMASTER: Send address changes to Journal of Neuro- Ophthalmology, P. O. Box 1550, Hagerstown, MD 21740. Contents ( continued) 264 Seesaw Nystagmus Following Whole Brain Irradiation and Intrathecal Methotrexate John A. Epstein, Mark L. Moster, and Michael Spiritos 266 Visual Function and Quality of Life Among Patients with Giant Cell ( Temporal) Arteritis Mark J. Kupersmith, Robert Speira, Regina Langer, Margorie Richmond, Margaret Peterson, Harry Speira, Hal Mitnick, and Stephen Paget 274 Pneumocystis carinii Granuloma of the Optic Nerve: A Histopathologic Case Report David L. Knox and Wm. Richard Green Photo Essay 276 Nerve Fiber Bundle Visual Field Defect Resulting from a Giant Peripapillary Cotton- Wool Spot Edward Chaum, Richard D. Drewry, Gerald T. Ware, and Steve Charles NANOS Symposium on Optic Neuritis and Multiple Sclerosis 279 Evolving Concepts in the Pathogenesis of Multiple Sclerosis and Their Therapeutic Implications Richard A. Rudick 284 Contemporary Immunomodulatory Therapy for Multiple Sclerosis Richard A. Rudick 292 The Controlled High Risk Avonex ® Multiple Sclerosis Trial ( CHAMPS STUDY) Steven L. Galetta 296 Clinical Outcome Measures for Research in Multiple Sclerosis Laura J. Balcer 302 Optic Neuritis: Historical Aspects Nicholas J. Volpe Letters to the Editor 310 Comparison of the ONTT Intravenous Group and the CHAMPS Placebo Group Roy W. Beck Instructions for Authors appears in this issue. Lippincott Williams & Wilkins, Inc., cannot be held responsible for errors or for any consequences arising from the use of the information contained in this journal. The appearance of advertising in this journal does not constitute an endorsement or approval by Lippincott Williams & Wilkins, Inc., of the quality or value of the product advertised or of the claims made for it by its manufacturer. PERMISSION TO PHOTOCOPY ARTICLES: This publication is protected by copyright. Permission to photocopy must be secured in writing from: Permissions Dept., Lippincott Williams & Wilkins, 530 Walnut Street, Philadelphia, PA 19106- 3621; FAX: [phone]; or Copyright Clearance Center ( CCC), 222 Rosewood Dr., Danvers, MA 01923; FAX: [phone]; or UMI, Box 49, 300 North Zeeb Road, Ann Arbor, MI 48106- 1346; FAX: [phone]. Address for subscription information, orders, or changes of address ( except Japan): 16522 Hunters Green Parkway, Hagerstown, MD 21740- 2116, or call 1- 800- 638- 3030; in Maryland call collect 301- 714- 2300. Subscribers requiring an address change must submit an old mailing label and their new address, including the zip code. No claims for copies lost in the mail can be allowed unless they are received within 90 days of the date of issue. Claims for issues lost as a result of insufficient notice of change of address will not be honored. Advertising inquiries should be directed to Renee Artuso, Lippincott Williams & Wilkins, 530 Walnut Street, Philadelphia, PA 19106- 3621. Fax: ( 516) 741- 2247. Contents ( continued) Neuro- Ophthalmology At Large 311 The Fifth European Neuro- Ophthalmological Society ( EUNOS) Meeting, Tubingen, Germany, July 22- 26, 2001 Jonathan D. Trobe Book Reviews 316 Neuro- Ophthalmology: Diagnosis and Management Ralph A. Sawyer 316 Atlas of Eyelid and Conjunctival Tumors Craig E. Geist 317 Atlas of Intraocular Tumors Craig E. Geist 318 Atlas of Orbital Tumors Craig E. Geist 319 Atlas of Pediatric Ophthalmology and Strabismus Surgery Sean P. Donahue 319 Immuno- Ophthalmology Michael S. Vaphiades 320 Mucosal Immunology and Ocular Disease Alan G. Palestine 320 The Autonomic Nervous System and Its Effectors Safwan Jaradeh NANOS News 322 Reorganization at NANOS Neil R. Miller 326 Calendar 327 Author Index 330 Subject Index Manuscripts should be submitted to Jonathan D. Trobe, MD, Editor- in- Chief, Journal of Neuro- Ophthalmology, Kellogg Eye Center, Department of Ophthalmology, 1000 Wall Street, Ann Arbor, MI 48105.