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Show HoaX. Departments of Medicine and Nephrology Research Faculty Sponsor Bellamkonda K. Kishore Teri Jo Mauch IMMUNOHISTOCHEMICAL LOCALIZATION OF P2Y2 RECEPTOR IN EMBRYONIC MOUSE Hoa X. Phan1,4 (Teri Jo Mauch2 and Bellamkonda K. Kishore1,3,4) Departments of ' Medicine, 2Pediatrics and 3Physiology, University of Utah Health Sciences Center, and 4Nephrology Research, VA Salt Lake City Health Care System Recent advances in developmental biology highlighted the linkage of several adulthood disorders to derangements during embryonic development especially during the period of organogenesis and differentiation. It is becoming increasingly clear that many of the childhood or even adult onset diseases or disorders in fact have their roots of origin while the individual is still in the mother's womb in embryonic form. In order to prevent such developmental disorders, it is essential to gain a comprehensive knowledge of the developmental pattern or ontogeny of key regulatory molecules, such as membrane receptors, channels or transporters. Knowledge gained from such studies will enable us to gain insights into the critical aspects of the development of vital organs such as brain, heart, lung, liver and kidneys. Such studies will also help us to identify the time points during embryonic development, when the individual is particularly vulnerable to damaging effects of external influences, such as nutrition, medications, alcohol and nicotine. P2Y2 receptor is a widely distributed extracellular nucleotide receptor, activation of which elicits a variety of biological responses, such as transport of water and salts across cell membranes, secretion of hormones, growth and differentiation of cells etc. In view of these characteristics of P2Y2 receptor, we examined the temporal and spatial expression pattern of its protein in embryonic mouse during organogenesis and differentiation. Our results document wide temporal and spatial expression pattern of P2Y2 receptor during organogenesis, which suggests that this receptor may play an important role in embryonic development and differentiation. Further studies are needed to understand the role played by P2Y2 receptor in the development and differentiation of each vital organ. |