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Show BORON POLYANION DENDRON FOR NEUTRON CAPTURE THERAPY AND SYNOVECTOMY Laura P. Hofer, (llya Zharov) Department of Chemistry A description of the synthesis of a dendron made-up of 2,2-Bis (hydroxymethyl) propionic acid with poylanionic boron clusters. The convergent synthesis provides a pathway for the quantitative growth of a multiple generation dendron comprised of benzyl bromide as the protecting group and 3-hydroxy-2-hydroxymethyl-2-methyl-propionic acid as the acylating agent, to be coupled with a carboranyl terminus. This compound can be viewed as a "bioden-dron,"[l] assembled from biodegradable building blocks and coupled to boron containing moieties that are water-soluble and are limited to a minimal toxic grade. The flexible chemistry employed allows for variability in the basic design, permitting its conversion into a range of products. Specifically, boron polyanion dendrons can be derived from this fundamental framework and applied to Boron Neutron Capture Therapy to cure tumors. |