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Show phism studied and suicide completion in the Utah cohort. These results are contradictory to recent studies by Zill et al., who reported an association between the SNP used in the study and major depression (2004a) and also completed suicide (2004b). Zill et al. studied a Southern German population, whereas our study encompassed suicide completers from the Intermountain West (Utah). In addition to the results listed in Table 1, secondary statistical analysis did not indicate an association between suicide completion and the TPH2 SNP, when TPH1 alleles are held constant. Table 1: Analysis of TPH2 Allele Frequencies in Suicide Completer Cohort Subjects AA AG GG A G X2 P value Controls 15 105 Suicide Completers 7 88 277 102 642 0.13 0.72 Youth (0-21) 2 19 85 23 189 0.21 0.64 Adult (22+) 5 69 192 79 453 0.44 0.51 Male 5 77 228 87 533 0.2 0.66 Female 2 11 49 15 109 0.009 0.92 Violent 6 73 237 85 547 0.079 0.78 Violent Youth 2 19 72 23 163 0.0012 0.97 Violent Adults 4 54 165 62 384 0.16 0.69 Nonviolent 1 15 40 17 95 0.35 0.55 Addictive drugs 5 61 158 71 377 0.82 0.36 Smokers3 19 68 10 140 2.7 0.1 Alcohol 2 30 68 34 166 1.17 0.28 Drugs 3 30 92 36 214 0.25 0.62 Depression 5 43 122 53 287 0.67 0.41 Reference: Caspi A, Sugden K, Moffitt TE, et al. 2003. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301(56311:386-389. www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs Zill P, Baghai TC, Zwanzger et al. 2004a. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psych (online pub.) 1-7.ZHI P, Buttner A, Eisenmenger W, Moller, H-J, Bondy B, Ackenheil M. 2004b. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psych 56:581-586. |
