Contents

The Treatment of Neuromyelitis Optica

Update item information
Title Journal of Neuro-Ophthalmology, March 2014, Volume 34, Issue 1
Publisher Lippincott, Williams & Wilkins
Date 2014-03
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s67979sg
Setname ehsl_novel_jno
Date Created 2015-03-24
Date Modified 2020-03-03
ID 227572
Reference URL https://collections.lib.utah.edu/ark:/87278/s67979sg

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Title The Treatment of Neuromyelitis Optica
Creator Kowarik, Markus C; Soltys, John; Bennett, Jeffrey L
Affiliation Departments of Neurology (MCK, JLB) and Ophthalmology (JS, JLB), University of Colorado Denver, Denver, Colorado; and Neuroscience Program (MCK, JS, JLB), University of Colorado Denver, Denver, Colorado
Subject Animals; Autoimmunity; Humans; Immunosuppression; Immunosuppressive Agents; Neuromyelitis Optica
Abstract Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system directed against astrocytes. Initially diagnosed in individuals with monophasic or relapsing optic neuritis and transverse myelitis, NMO is now recognized as a demyelinating disorder with pleiotropic presentations due to the identification of a specific autoantibody response against the astrocyte water channel aquaporin-4 in the majority of individuals. As visual impairment and neurologic dysfunction in NMO are commonly severe, aggressive treatment of relapses and prophylactic immunomodulatory therapy are the focus of treatment. Although there are no approved treatments for NMO, medications and therapeutic interventions for acute and chronic treatment have been the subject of retrospective study and case reports. The goal of this review is to familiarize the reader with biologic and clinical data supporting current treatments in NMO and highlight future strategies based on advancements in our understanding of NMO pathogenesis.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2014-03
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
Setname ehsl_novel_jno
Date Created 2015-03-24
Date Modified 2015-03-24
ID 227557
Reference URL https://collections.lib.utah.edu/ark:/87278/s67979sg/227557