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Downbeat Nystagmus Secondary to Familial Hemophagocytic Lymphohistiocytosis

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Title Journal of Neuro-Ophthalmology, March 2014, Volume 34, Issue 1
Publisher Lippincott, Williams & Wilkins
Date 2014-03
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s67979sg
Setname ehsl_novel_jno
Date Created 2015-03-24
Date Modified 2020-03-03
ID 227572
Reference URL https://collections.lib.utah.edu/ark:/87278/s67979sg

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Title Downbeat Nystagmus Secondary to Familial Hemophagocytic Lymphohistiocytosis
Creator Cai, Cindy X; Siringo, Frank S; Odel, Jeffrey G; Lignelli-Dipple, Angela; Lanzman, Bryan A; Gindin, Tatyana; Filipovich, Alexandra H
Affiliation Columbia University College of Physicians and Surgeons (CXC), New York, New York; Departments of Ophthalmology (FSS, JGO), Radiology (AL), and Pathology (TG); Columbia University Medical Center, New York Presbyterian Hospital, New York, New York; and Department of Clinical Immunology (AHF), Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, Ohio
Subject Biopsy; Bone Marrow; Brain; Diagnosis, Differential; Eye Movements; Female; Follow-Up Studies; Humans; Infant; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Nystagmus, Pathologic
Abstract Hemophagocytic lymphohistiocytosis is a rare autosomal recessive disorder characterized by severe inflammation induced by defective natural killer cell function, which triggers a state of highly stimulated but ineffective immune response. This disorder can affect multiple organ systems, and neurologic manifestations include irritability, seizures, impaired consciousness, meningismus, and cranial nerve palsies. We describe a unique case of hemophagocytic lymphohistiocytosis in which downbeat nystagmus developed due to cerebellar swelling with compression of the cervicomedullary junction.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2014-03
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
Setname ehsl_novel_jno
Date Created 2015-03-24
Date Modified 2015-03-24
ID 227553
Reference URL https://collections.lib.utah.edu/ark:/87278/s67979sg/227553