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Retinal Nerve Fiber Layer Thickness, Brain Atrophy, and Disability in Multiple Sclerosis Patients

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Title Journal of Neuro-Ophthalmology, March 2014, Volume 34, Issue 1
Date 2014-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s67979sg
Setname ehsl_novel_jno
ID 227572
Reference URL https://collections.lib.utah.edu/ark:/87278/s67979sg

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Title Retinal Nerve Fiber Layer Thickness, Brain Atrophy, and Disability in Multiple Sclerosis Patients
Creator Abalo-Lojo, Jose Manuel; Limeres, Carmen Carollo; Gmez, Manuel Arias; Baleato-Gonzlez, Sandra; Cadarso-Surez, Carmen; Capens-Tom, Carmen; Gonzalez, Francisco
Affiliation Service of Ophthalmology (JMA-L, CC-T, FG), Complexo Hospitalario Universitario de Santiago de Compostela, La Corua, Spain; Department of Statistics (CCL, CC-S), School of Medicine, University of Santiago de Compostela, Spain; Service of Neurology (MAG), and Radiology (SBG), Complexo Hospitalario Universitario de Santiago de Compostela, Spain; Department of Surgery and CIMUS (FG), University of Santiago de Compostela, Spain; and Insituto de Investigacion Sanitaria (FG), Santiago de Compostela, Spain
Abstract To study the relationship between retinal nerve fiber layer (RNFL) thickness and brain atrophy using magnetic resonance imaging (MRI) with bicaudate ratio (BCR) in patients with multiple sclerosis (MS) with different levels of disease severity. We also assessed whether RNFL thickness correlated with Expanded Disability Status Scale (EDSS) score. The participants consisted of 88 patients with MS and 59 age- and sex-matched healthy control subjects. Eleven patients had clinically isolated syndrome (CIS), 68 patients had relapsing-remitting MS (RR-MS), and 9 patients had secondary progressive MS. Patients and controls were evaluated using optical coherence tomography (OCT, Cirrus) and scanning laser polarimetry with variable corneal compensation (GDx VCC). Patients underwent the same brain MRI scanning protocol. Disability was evaluated according to the EDSS. The BCR was calculated by dividing the minimum intercaudate distance by brain width along the same level. The BCR was higher in patients with MS (0.12 0.03) than in controls (0.08 0.009) (P < 0.001). OCT average RNFL thickness in patients with MS was significantly lower (84.51 14.27 ?m) than in control subjects (98.44 6.83 ?m). BCR was correlated with OCT average RNFL thickness (r = -0.48, P = 0.002) in patients with MS without optic neuritis. Significant correlations were found between average RNFL thickness and EDSS (r = -0.43, P = 0.003). Additionally, there were correlations between BCR with GDx parameters in patients with MS without optic neuritis. This study shows that RNFL thickness correlates with BCR and with MS subtypes. Additionally, our study indicates that OCT is better suited for MS assessment than GDx. We conclude that the damage of retinal axons appears related to brain damage in patients with MS.
Subject Adult; Atrophy; Brain; Disability Evaluation; Female; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis, Relapsing-Remitting; Nerve Fibers; Optic Neuritis; Retinal Ganglion Cells; Retrospective Studies; Scanning Laser Polarimetry; Severity of Illness Index; Tomography, Optical Coherence
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Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227545
Reference URL https://collections.lib.utah.edu/ark:/87278/s67979sg/227545
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