| Title |
Fingolimod Therapy and Macular Hemorrhage |
| Creator |
Bhatti, M Tariq; Freedman, S Mitchell; Mahmoud, Tamer H |
| Affiliation |
Departments of Ophthalmology (MTB, THM) and Medicine (Division of Neurology) (MTB), Duke Eye Center and Duke University Medical Center, Durham, North Carolina; and Raleigh Neurology Associates, PA (SMF), Raleigh, North Carolina |
| Abstract |
A 54-year-old woman with relapsing-remitting multiple sclerosis (MS) developed visual loss in her left eye due to a macular hemorrhage 11 months after starting fingolimod. Visual acuity was 20/80 in the left eye, with a dense retinal hemorrhage involving the fovea with adjacent hard exudate and macular thickening confirmed by spectral domain optical coherence tomography. Three months after stopping fingolimod, vision in the left eye improved to 20/30 with resolution of the macular hemorrhage and exudates. Fingolimod has been associated with macular edema, but prior to this report, the authors are unaware of it causing a macular hemorrhage in a MS patient. The authors speculate that the macular hemorrhage may be due to a disruption of cellular adhesions between vascular endothelial cells that maintain the inner blood-retinal barrier. |
| Subject |
Blindness; Female; Fluorescein Angiography; Hemorrhage; Humans; Immunosuppressive Agents; Macula Lutea; Middle Older people; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Sphingosine; Tomography, Optical Coherence |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
227515 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6c282jn/227515 |
