| Title |
Small Cell Lung Carcinoma Presenting as Collapsin Response-Mediating Protein CRMP-5 Paraneoplastic Optic Neuropathy |
| Creator |
Sheorajpanday, R; Slabbynck, H; Van De Sompel, W; Galdermans, D; Neetens, I; De Deyn, PP |
| Affiliation |
Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium. |
| Abstract |
A 77-year-old woman presenting with progressive visual loss in both eyes was found to have small cell lung cancer. Assay for collapsin response-mediating protein (CRMP) -5 was positive suggesting a paraneoplastic optic neuropathy (PON). During treatment of the small cell lung cancer, the patient died of pneumonia and autopsy disclosed neuropathologic abnormalities consistent with PON. This is only the second case of CRMP-5-confirmed PON to report neuropathologic findings. |
| Subject |
Older people; Antibodies, Neoplasm, blood; Carcinoma, Small Cell, complications; Female; Humans; Magnetic Resonance Imaging, methods; Nerve Tissue Proteins, immunology; Nerve Tissue Proteins, metabolism; Optic Nerve Diseases, metabolism; Paraneoplastic Polyneuropathy, etiology; Paraneoplastic Polyneuropathy, metabolism; Paraneoplastic Polyneuropathy, pathology; Semaphorin-3A, metabolism |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225521 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6s217mp/225521 |
