Small Cell Lung Carcinoma Presenting as Collapsin Response-Mediating Protein CRMP-5 Paraneoplastic Optic Neuropathy

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Title Journal of Neuro-Ophthalmology, September 2006, Volume 26, Issue 3
Date 2006-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6s217mp
Setname ehsl_novel_jno
ID 225538
Reference URL https://collections.lib.utah.edu/ark:/87278/s6s217mp

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Title Small Cell Lung Carcinoma Presenting as Collapsin Response-Mediating Protein CRMP-5 Paraneoplastic Optic Neuropathy
Creator Sheorajpanday, R; Slabbynck, H; Van De Sompel, W; Galdermans, D; Neetens, I; De Deyn, PP
Affiliation Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium.
Abstract A 77-year-old woman presenting with progressive visual loss in both eyes was found to have small cell lung cancer. Assay for collapsin response-mediating protein (CRMP) -5 was positive suggesting a paraneoplastic optic neuropathy (PON). During treatment of the small cell lung cancer, the patient died of pneumonia and autopsy disclosed neuropathologic abnormalities consistent with PON. This is only the second case of CRMP-5-confirmed PON to report neuropathologic findings.
Subject Older people; Antibodies, Neoplasm, blood; Carcinoma, Small Cell, complications; Female; Humans; Magnetic Resonance Imaging, methods; Nerve Tissue Proteins, immunology; Nerve Tissue Proteins, metabolism; Optic Nerve Diseases, metabolism; Paraneoplastic Polyneuropathy, etiology; Paraneoplastic Polyneuropathy, metabolism; Paraneoplastic Polyneuropathy, pathology; Semaphorin-3A, metabolism
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225521
Reference URL https://collections.lib.utah.edu/ark:/87278/s6s217mp/225521