| Title |
A Multiple Sclerosis-Like Illness in a Man Harboring the mtDNA 14484 Mutation |
| Creator |
Bhatti, MT; Newman, NJ |
| Affiliation |
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA. |
| Abstract |
In most cases of Leber's hereditary optic neuropathy (LHON) the only clinical manifestation is visual loss. A multiple sclerosis-like illness has been infrequently reported in association with LHON. Most patients are women harboring the mtDNA 11778 mutation. We present a young man with clinical and paraclinical evidence of a demyelinating process with profound bilateral visual loss who harbored the mtDNA 14484 mutation associated with LHON. |
| Subject |
Adult; Blindness/genetics; Brain/pathology; DNA, Mitochondrial/genetics; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis/diagnosis; Multiple Sclerosis/genetics; Optic Atrophies, Hereditary/diagnosis; Optic Atrophies, Hereditary/genetics; Optic Nerve/pathology; Point Mutation; Spinal Cord/pathology; Visual Acuity |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
224952 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6hm8fhh/224952 |
