Contents | 6 of 33

Evaluation of Fixation Pattern and Reading Ability in Patients With Leber Hereditary Optic Neuropathy

Update Item Information
Title Journal of Neuro-Ophthalmology, December 2013, Volume 33, Issue 4
Date 2013-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6c282jn
Setname ehsl_novel_jno
ID 227537
Reference URL https://collections.lib.utah.edu/ark:/87278/s6c282jn

Page Metadata

Title Evaluation of Fixation Pattern and Reading Ability in Patients With Leber Hereditary Optic Neuropathy
Creator Altpeter, Elke K; Blanke, Bjrn R; Leo-Kottler, Beate; Nguyen, Xuan N; Trauzettel-Klosinski, Susanne
Affiliation Low Vision Clinic and Research Laboratory (EKA, BRB, XNN, ST-K), and University Eye Clinic (BL-K), Center for Ophthalmology, University of Tbingen, Tbingen, Germany
Abstract Leber hereditary optic neuropathy (LHON) is characterized by progressive loss of central vision leading to impaired reading ability. The aim of this study was to evaluate sensory adaptation and reading ability in LHON patients. This prospective pilot study included 12 male patients with a clinical diagnosis and a positive genetic analysis of LHON, who matched the inclusion criteria of a central scotoma on visual field testing and the use of magnifying aids to read. Examination included best-corrected visual acuity, magnification need, reading speed, and evaluation of fixation by corneal reflexes and by Rodenstock scanning laser ophthalmoscope (SLO). Central scotoma was assessed by conventional perimetry (Tbingen Automated Perimeter) and microperimetry (NIDEK MP1). Mean magnification need was 13.2 7.3-fold (range: 2- to 25-fold). Mean reading speed was 53 18 words per minute (WPM) (range: 24-85 WPM). With automated perimetry, all patients showed central scotomas with a mean radius of 13 7 (range: 1-3 ) in the better eye. Microperimetry in all patients showed fenestrated central scotomas. Eccentric fixation with a preferred retinal locus (PRL) was detected with SLO examination and microperimetry correlated well in 11 of 12 patients. The SLO results showed no systematic pattern in the placement of the PRL; however, 7 of 12 patients (58%) placed their PRL in an unfavorable location left or below the fovea. In 8 of 12 patients, fixation was unstable. Between reading speed and central scotoma size, there was a statistically significant negative correlation (P = 0.021, r = -0.65). The percentage of unfavorable PRL locations was extremely high compared with other disorders with central scotomas. Unstable fixation and fenestrated central scotomas led to difficulties in reading. Early rehabilitation and, if necessary, eccentric viewing training should be considered in LHON patients.
Subject Adaptation, Ocular; Older people; Diagnostic Techniques, Ophthalmological; Dyslexia; Fixation, Ocular; Humans; Male; Middle Older people; Ocular Motility Disorders; Optic Atrophy, Hereditary, Leber; Pilot Projects; Reading; Scanning Laser Polarimetry; Scotoma; Visual Field Tests; Young Adult
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227509
Reference URL https://collections.lib.utah.edu/ark:/87278/s6c282jn/227509
Back to Search Results