Reflection-based imaging of macular pigment distributions in infants and children

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Publication Type pre-print
School or College School of Medicine
Department Ophthalmology
Creator Bernstein, Paul S.
Other Author Sharifzadeh, Mohsen; Gellermann, Werner
Title Reflection-based imaging of macular pigment distributions in infants and children
Date 2013-01-01
Description We have developed a reflection-based capability of the RetCam® platform, an FDA-cleared pediatric retinal-imaging instrument, for the purpose of measuring macular pigment levels as well as their spatial distributions in infants and children. Our modifications include narrow-band blue-wavelength excitation of the macular pigment absorption in combination with spectrally selective blue-wavelength readout of the reflection signals received by the instrument's CCD detector array. Furthermore, an algorithm is developed that allows the computation of optical density maps for the macular pigment relative to peripheral retinal areas. This made it possible for the first time to directly measure macular pigment levels and their spatial features in the developing human retina. In contrast to adults, infants with measurable pigment levels had almost exclusively a narrow, circularly symmetric, pigment distribution. The described methodology holds promise for future investigations into the role of macular pigment in the developing human retina and the effect of dietary interventions in diseases resulting from a lack of normal carotenoid levels.
Type Text
Publisher International Society for Optical Engineering (SPIE)
Volume 18
Issue 11
First Page 116001-1
Last Page 116001-9
Language eng
Bibliographic Citation Sharifzadeh, M., Bernstein, P. S., & Gellermann, W. (2013). Reflection-based imaging of macular pigment distributions in infants and children. Journal of Biomedical Optics, 18(11), 116001-1-116001-9.
Rights Management (c)Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx. DOI: 10.1117/1.JBO.18.11.116001.
Format Medium application/pdf
Format Extent 5,517,682 bytes
Identifier uspace,18447
ARK ark:/87278/s6962sk8
Setname ir_uspace
Date Created 2014-03-17
Date Modified 2021-05-06
ID 711871
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