High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Kestle, John R. W.
Other Author Fassett, Daniel R.; Pingree, James
Title High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients
Date 2005
Description P Myxopapillary ependymomas (MPEs) have historically been thought to be benign tumors occurring most frequently in adults. Only 8 to 20% of these tumors occur in the first two decades of life, making this tumor a rarity in pediatric neurosurgery. Five patients with intraspinal MPEs were treated by the authors between 1992 and 2003. Four (80%) of these five patients suffered from disseminated disease of the central nervous system (CNS) at the time of presentation; this incidence is much higher than that reported in the combined adult and pediatric literature. Combining five pediatric case series reported in the literature with the present series, the authors review a total of 26 cases of pediatric patients with intraspinal MPEs. In nine cases (35%) CNS metastases occurred. In those cases in which patients underwent screening for CNS tumor dissemination, however, the incidence of disseminated disease was 58% (seven of 12 patients). In pediatric patients MPEs may spread throughout the CNS via cerebrospinal fluid pathways; therefore, MR imaging of the entire CNS axis is recommended at both presentation and follow-up review to detect tumor dissemination.
Type Text
Publisher American Association of Neurological Surgeons (AANS)
Volume 102
Issue 1
First Page 59
Last Page 64
Subject Myxopapillary ependymoma; Tumor dissemination
Subject LCSH Metastasis; Pediatric neurology; Ependyma -- Tumors
Language eng
Bibliographic Citation Fassett, D. R., Pingree, J., & Kestle, J. R. W. (2005). High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. Journal of Neurosurgery, 102(1), 59-64.
Rights Management (c) American Association of Neurological Surgeons
Format Medium application/pdf
Format Extent 93,645 bytes
Identifier ir-main,13200
ARK ark:/87278/s6x645n2
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 707240
Reference URL https://collections.lib.utah.edu/ark:/87278/s6x645n2
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