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126 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: correlation between radiographic and functional outcomeStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. There is insufficient evidence to recommend a treatment guideline. Options. It is recommended that when performing lumbar arthrodesis for degenerative lumbar disease, strategies to achieve successful radiogr...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines; Functional outcome; Radiographic outcome2005
127 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 6: magnetic resonance imaging and discography for patient selection for lumbar fusionStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. 1) It is recommended that MR imaging be used as a diagnostic test instead of discography for the initial evaluation of patients with chronic low-back pain. 2) It is recommended that MR imaging-documented dis...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines; Patient selection; Discography2005
128 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 7: intractable low-back pain without stenosis or spondylolisthesisStandards. Lumbar fusion is recommended as a treatment for carefully selected patients with disabling lowback pain due to one- or two-level degenerative disease without stenosis or spondylolisthesis. Guidelines. There is insufficient evidence available to support a treatment guideline. Options. An...Fusion; Lumbar spine; Degenerative disease; Low back pain2005
129 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 8: lumbar fusion for disc herniation and radiculopathyStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. There is insufficient evidence to recommend a treatment guideline. Options. 1) Lumbar spinal fusion is not recommended as routine treatment following primary disc excision in patients with a herniated lumbar...Fusion; Lumbar spine; Degenerative disease; Lumbar fusion; Disc herniation; Radiculopathy2005
130 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 9: fusion in patients with stenosis and spondylolisthesisGuidelines. The performance of a lumbar PLF is recommended for patients with lumbar stenosis and associated degenerative spondylolisthesis who require decompression. There is insufficient evidence to recommend a treatment guideline. Options. Pedicle screw fixation as an adjunct to lumbar PLF should ...Fusion; Lumbar spine; Degenerative disease; Lumbar fusion2005
131 Couldwell, William T.Harvey cushing and oskar hirsch: early forefathers of modern transsphenoidal surgeryThe transnasal transsphenoidal approach is the preferred route for removal of most lesions of the sella turcica. The concept of transnasal surgery traversing the sphenoid sinus to reach the sella has existed for nearly a century. A comprehensive historical overview of the evolution of transsphenoida...2005
132 Couldwell, William T.Hearing restoration after resection of an intracanalicular vestibular schwannoma: a role for emergency surgery?Patients with vestibular schwannomas (VSs) most commonly present with sensorineural hearing loss, which is often insidious or gradual. Up to 26% of patients may present with sudden hearing loss, however, which poses an important surgical challenge. Sudden hearing loss has been attributed to spasm or...Vestibular schwannoma; Hearing preservation2002
133 Couldwell, William T.; Schloesser, Peter E.Hemorrhage from moyamoya-like vessels associated with a cerebral arteriovenous malformationThe authors describe a case of subarachnoid hemorrhage from moyamoya-like vessels associated with an arteriovenous malformation (AVM) in a 44-year-old Hispanic man who presented with severe headache. The AVM was located in the left parietal lobe and the ipsilateral middle cerebral artery was occlude...Moyamoya-like vessels; Arteriovenous malformation; Ischemia MeSH: Arteriovenous malformations2004
134 Couldwell, William T.Hemorrhagic and nonhemorrhagic Rathke cleft cysts mimicking pituitary apoplexyObject. Rathke cleft cysts (RCCs) are infrequently symptomatic, and apoplexy is one of the most unusual presentations. Only a few cases of apoplexy associated with RCCs have been reported, and their clinical, imaging, surgical, and pathological features are poorly understood. In the cases that have ...2008-01-01
135 Huang, Lin EricHIF-1? mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progressionAlthough tumor progression involves genetic and epigenetic alterations to normal cellular biology, the underlying mechanisms of these changes remain obscure. Numerous studies have shown that hypoxia-inducible factor 1? (HIF-1?) is overexpressed in many human cancers and up-regulates a host of hypoxi...
136 Kestle, John R. W.High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patientsP Myxopapillary ependymomas (MPEs) have historically been thought to be benign tumors occurring most frequently in adults. Only 8 to 20% of these tumors occur in the first two decades of life, making this tumor a rarity in pediatric neurosurgery. Five patients with intraspinal MPEs were treated by t...Myxopapillary ependymoma; Tumor dissemination2005
137 Kestle, John R. W.High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patientsP Myxopapillary ependymomas (MPEs) have historically been thought to be benign tumors occurring most frequently in adults. Only 8 to 20% of these tumors occur in the first two decades of life, making this tumor a rarity in pediatric neurosurgery. Five patients with intraspinal MPEs were treated by t...2005-01
138 Couldwell, William T.History and evolution of transsphenoidal surgeryInitial attempts at transcranial approaches to the pituitary gland in the late 1800s and early 1900s resulted in a mortality rate that was generally considered prohibitive. Schloffer suggested the use of a transsphenoidal route as a safer, alternative approach to the sella turcica. He reported the f...Neurosurgical history; Transsphenoidal surgery; Pituitary tumor2001
139 Couldwell, William T.Hypericin: a potential antiglioma therapyHYPERICIN, A POLYCYCLIC aromatic dione isolated from plants, is presently being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. In addition, it is known to be a potent protein kinase C inhibitor. To evaluate its potential as an inhibitor o...Hypericin; Protein kinase C; Glioma; Brain neoplasm1994
140 Couldwell, William T.; Osborne, Anne G.Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literatureBackground: Hypertrophic olivary degeneration (HOD) is a pathological phenomenon that occurs after injury to the dentato-olivary pathway. Its hallmarks include hypertrophy of the olive with increased T2 signal intensity on magnetic resonance imaging, and often manifests with palatal tremor and osci...Hypertrophic olivary degeneration; Surgery; Cavernous malformation; Brainstem2008
141 Couldwell, William T.; Schmidt, Meic H.; MacDonald, Joel D.; Jensen, Randy L.Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinusStereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary,...Pituitary tumor; Cavernous sinus; Hypopituitarism; Stereotactic radiosurgery; Transsphenoidal surgery; Pituitary transposition2003
142 Schmidt, Meic H.; MacDonald, Joel D.; Jensen, Randy L.; Couldwell, William T.Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinusStereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary,...Hypophysial transposition; Hypophysopexy; Pituitary tumors; Stereotactic radiosurgery; Pituitary transposition; Hypopituitarism2003
143 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysisOvercoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1α and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression pro...Glioblastoma multiforme; U-251; Hypoxia; Microarray analysis; Brain tumor; Depp; Astrocytoma2007
144 Couldwell, William T.Immunology and immunotherapy of intrinsic glial tumorsImmunological aspects of glial neoplasms have been actively investigated for the past several years with particular focus on academic, diagnostic, and therapeutic objectives. As more knowledge is acquired about the cellular events relating to tumor behavior the more it appears that the immune system...Immunology; Glial tumors1990
145 Couldwell, William T.Increased invasive capacity of connexin43-overexpressing malignant glioma cellsObject. Malignant glioma cells, similar to astrocytes, express connexin43 (Cx43) universally but at widely varied levels. Data from previous studies have demonstrated that malignant glioma cells form functional gap junction channels among themselves as well as with astrocytes and that such a communi...2003-12
146 Couldwell, William T.Increasing exposure of the petrous internal carotid artery for revascularization using the transzygomatic extended middle fossa approach: a cadaveric morphometric studyWhen internal carotid artery (ICA) sacrifice is planned in the management of difficult tumors or aneurysms at the cranial base, the petrous ICA may be a useful site for anastomosis for interpositional vascular bypass. However, exposure of the artery and performing an anastomosis in this region may...Revascularization; Internal carotid artery; Cranial base tumors; Giant aneurysms; Interpositional bypass; Surgical approach; Middle fossa2006
147 Kestle, John R. W.; Simon, Tamara DanielleInfection rates following initial cerebrospinal fluid shunt placement across pediatric hospitals in the United StatesObject. Reported rates of CSF shunt infection vary widely across studies. The study objective was to determine the CSF shunt infection rates after initial shunt placement at multiple US pediatric hospitals. The authors hypothesized that infection rates between hospitals would vary widely even after ...Shunt placement; Pediatric neurosurgery2009
148 Couldwell, William T.Inflammatory pseudotumor of the cavernous sinus and skull baseInflammatory pseudotumor is a non-neoplastic process of unknown etiology characterized by a proliferation of connective tissue with an inflammatory infiltrate. Intracranial inflammatory pseudotumors classically involve the cavernous sinus but can also occur in the supratentorial or infratentorial c...Intracranial neoplasm; Pseudotumor; Skull base2006
149 Couldwell, William T.Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic applicationProtein kinase C (PKC) is an enzyme involved in the regulation of cellular growth, proliferation, and differentiation in a number of tissues including the anterior pituitary, in which it is also believed to play a role in hormone secretion. Protein kinase C activity and expression have been found to...Apoptosis; Hypericin; Pituitary adenoma; Protein kinase C1996
150 Couldwell, William T.Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C systemThe protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administrat...Protein kinase C; Phorbol ester; Cell proliferation; Tumor cell growth; Astrocyte; Glioma; Immunohistochemistry1990
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