Comparable effects of DIGIBIND and DigiFab in thirteen digoxin immunoassays

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Publication Type Journal Article
Department Pathology
Program ARUP Institute for Clinical and Experimental Pathology
Creator Owen, William E.; Roberts, William L.
Other Author McMillin, Gwendolyn A.; Lambert, Thomas L.; De, Barun K.; Frank, Elizabeth L.; Bach, Phillip R.; Annesley, Thomas M.
Title Comparable effects of DIGIBIND and DigiFab in thirteen digoxin immunoassays
Date 2002
Description Digoxin is widely prescribed for the treatment of cardiac conditions (1). Because of its narrow therapeutic range, digoxin-related toxicity resulting from acute or chronic overdose is common. Metabolites of digoxin as well as related compounds, including digitoxin, tanshinones, bufandienolide, and oleander, can contribute to or independently produce digoxin toxicity (2,3). Digoxin toxicity can be rapidly and safely reversed by administration of anti-digoxin immune fragments (Fab) such as DIGIBIND ®, which has been available in the US since 1986. Therapeutic Fab products act by binding digoxin with high affinity (109-1010 L/mol), favoring movement of digoxin out of tissue and thus promoting elimination. Factors that impact dosing with Fab products include known or suspected digoxin load, patient weight and history, and renal function (4-7).
Type Text
Publisher American Association for Clinical Chemistry
Volume 48
Issue 9
First Page 1580
Last Page 1584
Subject DIGIBIND; DigiFab; Digoxin immunoassays; Digoxin toxicity
Subject LCSH Immunoassay; Digoxin; Digoxin -- Measurement
Language eng
Bibliographic Citation McMillin, G. A., Owen, W. E., Lambert, T. L., De, B. K., Frank, E. L., Bach, P. R., Annesley, T. M., & Roberts, W. L. (2002). Comparable effects of DIGIBIND and DigiFab in thirteen digoxin immunoassays. Clinical Chemistry, 48(9), 1580-4.
Rights Management (c)American Association for Clinical Chemistry
Format Medium application/pdf
Format Extent 161,842 bytes
Identifier ir-main,11558
ARK ark:/87278/s69p3k8z
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 707175
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