Protein kinase C and growth regulation in malignant gliomas

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Hinton, David R.; Law, Ronald E.
Title Protein kinase C and growth regulation in malignant gliomas
Date 1994
Description To the Editor: The presence of amplified growth factor systems in many tumor models, including malignant gliomas, raises the question of how such external signals are transduced into a transformed phenotype (increased proliferation, invasion, lack of contact inhibition, angiogenic capacity, etc.). In this regard, intracellular signal transduction systems a re likely to play a key role. Such amplified external signals, by way of transduction systems, may alter genomic expression to effect a change of the expression of structural or regulatory genes to produce the malignant phenotype. Furthermore, the complexity and multiplicity of the growth factor systems place therapeutic impetus upon determining events that follow growth factor/receptor binding. Determination of postbinding events may reveal common intracellular transduction mechanisms activated by these different signals.
Type Text
Publisher Wolters Kluwer (LWW)
Volume 35
Issue 6
First Page 1184
Last Page 1185
Subject Protein kinase C; Glioma; Brain neoplasm; protooncogenes; Apoptosis; Tamoxifen
Subject LCSH Gliomas -- Treatment; Protein kinases; Brain -- Cancer; Cellular signal transduction
Language eng
Bibliographic Citation Couldwell, W. T., Hinton, D. R., & Law, R. E. (1994). Protein kinase C and growth regulation in malignant gliomas [Letter to the editor]. Neurosurgery, 35(6), 1184-5.
Rights Management (c) Wolters Kluwer (LWW)
Format Medium application/pdf
Format Extent 973,345 bytes
Identifier ir-main,12986
ARK ark:/87278/s6vq3m4w
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 705601
Reference URL
Back to Search Results