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1 Kestle, John R. W.Shunt insertion in the summer: is it safe?Object. The potential for increased complications related to the arrival of new residents in July each year has not previously been demonstrated in the neurosurgical literature. The authors investigated this phenomenon in children undergoing cerebrospinal fluid shunt surgery. Methods. Data were ob...Ventriculoperitoneal shunt; July effect; Complication; Shunt insertion2006
2 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 12: pedicle screw fixation as an adjunct to posterolateral fusion for low-back painStandard. There is insufficient evidence to recommend a treatment standard. Guidelines. There is insufficient evidence to recommend a treatment guideline. Options. 1) Pedicle screw fixation is recommended as a treatment option for patients with low-back pain treated with PLF who are at high risk...Fusion procedures; Degenerative disease; Lumbar spine; Pedicle screw fixation; Posterolateral fusion; Low-back pain2005
3 Kestle, John R. W.; Brockmeyer, Douglas LeeEvaluation of the necessity of postoperative imaging after craniosynostosis surgeryObject. Childhood radiation exposure increases the lifetime risk of cancer from an estimated 0.07 to 0.35%. Neurological evaluation of patients after cranial vault reconstruction for synostosis repair is often complicated by pain medication, sedation, intubation, swelling, and dressings; therefore c...Computed tomography; Cranial vault reconstruction; Pediatric neurosurgery; Radiation dose; Postoperative imaging2007
4 Couldwell, William T.Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomasThe monoclonal antibody Ki-67 recognizes a nuclear antigen expressed in the G1, S, G2, and M phase of the cell cycle and has been used extensively as an indicator of cellular proliferation in malignant gliomas, both in the laboratory and clinically. Recently, protein kinase C (PKC) inhibitors have b...Brain neoplasm; Chemotherapy; Glioma; Monoclonal antibody; Ki-67; Protein kinase C; Tamoxifen1995
5 Schmidt, Meic H.Role of light-emitting diodes for photodynamic therapy of brain tumorsThe development of more effective light sources for Photodynamic Therapy (PDT) of brain tumors would be of benefit for both research and clinical application. In this study, the use of light-emitting diode arrays for PDT of brain tumors with Photofrin® porfimer sodium was investigated. An inflatabl...Aluminum Gallium Arsenide; Photodynamic therapy; Brain tumors; Photofrin1996
6 Kestle, John R. W.Lack of benefit of endoscopic ventriculoperitoneal shunt insertion: a multicenter randomized trialObject. Endoscopically assisted ventricular catheter placement has been reported to reduce shunt failure in uncontrolled series. The authors investigated the efficacy of this procedure in a prospective multicenter randomized trial. Methods. Children younger than 18 years old who were scheduled for t...Ventriculoperitoneal shunt; Shunt insertion; Shunt failure2003
7 Schmidt, Meic H.Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma modelPhotodynamic therapy was studied in dogs with and without posterior fossa glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at doses ranging from 0.75 to 4 mg/kg 24 hours prior to laser light irradiation in the posterior fossa. Tissue levels of Photofrin-l...Brain neoplasm; Posterior fossa; Photodynamic therapy; Glioblastomas; Dog; Photofrin-II; Canine glioma model1993
8 Dailey, Andrew T.; Brodke, Darrel S.Differences between neurosurgeons and orthopaedic surgeons in classifying cervical dislocation injuries and making assessment and treatment decisions: a multicenter reliability studyVariability exists in the management of cervical spinal injuries. The goal of this study was to assess the effect of training specialty (orthopedic surgery vs neurosurgery) on management of cervical dislocations.Cervical dislocation injuries; Classification; Orthopedic surgeons; Orthopaedic surgeons; Assessment decisions; Treatment decisions2008
9 Couldwell, William T.; Gottfried, Oren N.Too many? Too few. New study reveals current trends in U. S. neurosurgical workforceRemarkable changes in the neurosurgical specialty have taken place in the past 15 years. While advances in basic science have occurred and new technologies and therapies have proliferated, other, less propitious factors-such as the promises (some might say false promises) and hopes of managed care-h...2003-01-01
10 Couldwell, William T.Surgical approaches to petroclival meningiomas Part II: extended approachesIn Part I, the classification, clinical presentation, and upper and midclival surgical approaches were discussed. This lesson covers extended surgical approaches, results, complications, and adjuvant therapy.Petroclival meningiomas; Petroclivus; Surgical approach; Staged surgery; Complications; Adjuvant therapy; Radiosurgery; Resections1994
11 Couldwell, William T.Hypericin: a potential antiglioma therapyHYPERICIN, A POLYCYCLIC aromatic dione isolated from plants, is presently being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. In addition, it is known to be a potent protein kinase C inhibitor. To evaluate its potential as an inhibitor o...Hypericin; Protein kinase C; Glioma; Brain neoplasm1994
12 Couldwell, William T.; Schmidt, Meic H.; MacDonald, Joel D.; Jensen, Randy L.Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinusStereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary,...Pituitary tumor; Cavernous sinus; Hypopituitarism; Stereotactic radiosurgery; Transsphenoidal surgery; Pituitary transposition2003
13 Couldwell, William T.Definition of the role of contemporary surgical management in cisternal and parenchymatous cysticercosis cerebriWith increasing immigration from endemic regions, the incidence of neurocysticercosis in North America is rising. This retrospective study was undertaken to examine the role of surgery in those cases presenting with large cystic parenchymal and cisternal lesions in the current era of anthelminthic a...Brain cyst; Computed tomography; Neurocysticercosis; Magnetic resonance imaging; Praziquantel; Stereotaxis1991
14 Bisson, Erica F.Management of distraction injury of the lumbosacral junction with unilateral perched facetBackground: Traumatic unilateral facet dislocation without fracture is an uncommon injury of the lumbosacral junction. We describe a case of a unilateral perched L5-S1 facet causing axial back pain and radiculopathy provoked by motion. ...Spine surgery, Facet dislocation, operative management, trauma, neurosurgery2011-01-04
15 Couldwell, William T.Pallidotomy in advanced Parkinson's diseaseTo the Editor: We read with interest the comments published regarding our recent article on pallidotomy in patients with advanced Parkinson's disease (3). There seems to be confusion as to some of the technical methods used in creating the radiofrequency lesions in these patients. As noted in the Pa...Pallidotomy; Dyskinesia1995
16 Digre, Kathleen B.; Blumenthal, Deborah T.; Salzman, Karen L.; Jensen, Randy L.; Dunson, William A.Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis.A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-assoc...Paraneoplastic neurologic disorders; Encephalitis; Neoplasm;Herpes Simplex2006-07-11
17 Couldwell, William T.Increased invasive capacity of connexin43-overexpressing malignant glioma cellsObject. Malignant glioma cells, similar to astrocytes, express connexin43 (Cx43) universally but at widely varied levels. Data from previous studies have demonstrated that malignant glioma cells form functional gap junction channels among themselves as well as with astrocytes and that such a communi...2003-12
18 Couldwell, William T.Protein kinase C and growth regulation in malignant gliomasTo the Editor: The presence of amplified growth factor systems in many tumor models, including malignant gliomas, raises the question of how such external signals are transduced into a transformed phenotype (increased proliferation, invasion, lack of contact inhibition, angiogenic capacity, etc.). ...Protein kinase C; Glioma; Brain neoplasm; protooncogenes; Apoptosis; Tamoxifen1994
19 Couldwell, William T.No ordinary time, no ordinary men: the relationship between Harvey Cushing and Franklin D. Roosevelt, 1928-1939The authors elucidate the strong personal relationship that developed between Dr. Harvey Cushing and Franklin Delano Roosevelt (FDR) from 1928 to 1939, as manifested in their frequent letters to each other. The relationship was initiated by the marriage of their children. Through his correspondence ...2001
20 Schmidt, Meic H.NASA light-emitting diode medical program-progress in space flight and terrestrial applicationsThis work is supported and managed through the NASA Marshall Space Flight Center - SBIR Program. Studies on cells exposed to microgravity and hypergravity indicate that human cells need gravity to stimulate cell growth. As the gravitational force increases or decreases, the cell function responds in...Terrestrial applications; Cell growth; NASA; Microgravity environment2000
21 Couldwell, William T.Transmaxillary approach to the anterior cavernous sinus: a microanatomic studyOBJECTIVE: Several approaches to expose the anterior cavernous sinus have been used, such as frontotemporal, orbitofrontal, anterior subtemporal, and various transfacial approaches. In an effort to gain exposure to the anterior cavernous sinus without necessitating a craniotomy or wide transfacial ...Anterior cavernous sinus; Clivus; Cranial base; Maxillary sinus1997
22 Couldwell, William T.; Gottfried, Oren N.Surgical management of posterior petrous meningiomasPosterior petrous meningiomas (commonly termed posterior pyramid meningiomas and/or meningiomas of the posterior surface of the petrous pyramid) are the most common meningiomas of the posterior cranial fossa. They are located along the posterior surface of the temporal bone in the region of the cere...2003-01-01
23 Couldwell, William T.Resident curriculum guidelines for neurosurgeryThis curriculum was created to detail the body of knowledge that should be attained by an individual completing residency training in neurological surgery. The specific structure of resident education in neurological surgery is defined by the American Board of Neurological Surgery, and each program...Residency training; Neurological surgery2000
24 Couldwell, William T.Neurosurgical implications of allergic fungal sinusitisObject. Allergic fungal sinusitis (AFS) is a form of paranasal mycosis that often involves bone destruction and extension into the orbit and anterior skull base. Treatment consists of surgical extirpation and a course of corticosteroids. Despite frequent intracranial involvement, AFS is rarely repor...2004
25 Couldwell, William T.Comment on: Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trialsThe long-term consequences of adenovirus-mediated conditional cytotoxic gene therapy for gliomas remain uncharacterized. We report here detection of active brain inflammation 3 months after successful inhibition of syngeneic glioma growth. The inflammatory infiltrate consisted of activated macrophag...Brain inflammation; Herpes simplex virus-1; Thymidine kinase; Syngeneic glioma; Adenovirus-mediated gene therapy1994
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