Publication Type |
Journal Article |
School or College |
School of Medicine |
Department |
Neurosurgery |
Creator |
Schmidt, Meic H. |
Other Author |
Chang, Susan M.; Parney, Ian F.; McDermott, Michael; Barker, Fred G.; Huang, Wei; Laws, Edward R.; Lillehei, Kevin O.; Bernstein, Mark; Brem, Henry; Sloan, Andrew E.; Berger, Mitchel |
Title |
Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project |
Date |
2003 |
Description |
In many new clinical trials of patients with malignant gliomas surgical intervention is incorporated as an integral part of tumor-directed interstitial therapies such as gene therapy, biodegradable wafer placement, and immunotherapy. Assessment of toxicity is a major component of evaluating these novel therapeutic interventions, but this must be done in light of known complication rates of craniotomy for tumor resection. Factors predicting neurological outcome would also be helpful for patient selection for surgically based clinical trials. Methods. The Glioma Outcome Project is a prospectively compiled database containing information on 788 patients with malignant gliomas that captured clinical practice patterns and patient outcomes. Patients in this series who underwent their first or second craniotomy were analyzed separately for presenting symptoms, tumor and patient characteristics, and perioperative complications. Preoperative and intraoperative factors possibly related to neurological outcome were evaluated. |
Type |
Text |
Publisher |
American Association of Neurological Surgeons (AANS) |
Volume |
98 |
First Page |
1175 |
Last Page |
1181 |
Subject |
Perioperative complications; Neurological outcomes; Glioma Outcome Project |
Subject LCSH |
Gliomas; Gliomas -- Treatment; Craniotomy; Craniotomy -- Complications |
Language |
eng |
Bibliographic Citation |
Chang, S. M., Parney, I. F., McDermott, M., Barker, F. G., Schmidt, M. H., Huang, W., Laws, E. R., Lillehei, K. O., Bernstein, M., Brem, H., Sloan, A. E., & Berger, M. (2003). Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project. Journal of Neurosurgery, 98, 1175-81. |
Rights Management |
(c) American Association of Neurological Surgeons |
Format Medium |
application/pdf |
Format Extent |
60,033 bytes |
Identifier |
ir-main,12762 |
ARK |
ark:/87278/s68p6hw1 |
Setname |
ir_uspace |
ID |
704683 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68p6hw1 |